Document Detail


Atorvastatin attenuates cardiomyocyte loss in adult rats from protein-restricted dams.
MedLine Citation:
PMID:  18325463     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Statins are cholesterol-lowering drugs that have been proved to prevent cardiac events. Their direct effects on cardiac remodeling, when administered in programmed protein restricted animals, still are unknown. METHODS AND RESULTS: Wistar male 6-month-old offspring from dams fed normal protein (NP, 19% of protein) or low-protein (LP, 5% of protein) during pregnancy and first 10 days after birth were studied. After weaning, male pups were allocated to untreated or treated groups with atorvastatin (low and high doses, 5 or 30 mg.kg.day) in two different periods (from 21 days old to 3 months old and from 3 to 6 months old). The blood pressure (BP) was 30% greater in untreated LP offspring than in treated offspring (from 165 +/- 6 mm Hg to 127 +/- 3 mm Hg, P < .01). After 1 month of treatment, only untreated LP offspring continued with high BP. Compared with untreated LP offspring, atorvastatin reduced blood glucose (less 30%, P < .05) and cardiomyocyte size (less 24%, P < .05), whereas untreated LP offspring had greater interstitial fibrosis (plus 74%, P < .01), reduction of myocardial vascularization (less 25%, P < .01) and major reduction of cardiomyocyte number (less 38%, P < .01) than treated LP offspring. CONCLUSION: Atorvastatin from 3 to 6 months olds in both low and high doses (but not from 0 to 3 months) has beneficial effects improving myocardial vascularization by diminishing fibrosis and cardiomyocyte loss.
Authors:
Daniele Gonçalves Bezerra; Lívia Marinho Lacerda Andrade; Fernanda Ornellas Pinto da Cruz; Carlos Alberto Mandarim-de-Lacerda
Related Documents :
12601503 - Absence of reinforcing, mood and psychomotor performance effects of caffeine in habitua...
671093 - Effects of vitamin b-6 deficiency on the developing central nervous system of the rat. ...
3439943 - Protein, lactose and fat concentration of breast milk of mothers of term and premature ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiac failure     Volume:  14     ISSN:  1532-8414     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-07     Completed Date:  2008-05-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  151-60     Citation Subset:  IM    
Affiliation:
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Centre, Institute of Biology, State University of Rio de Janeiro, Av 28 de Setembro, 87 (fds)-20551-030 Rio de Janeiro, RJ, Brasil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Body Mass Index
Cardiomegaly
Diet, Protein-Restricted*
Fibrosis
Heptanoic Acids / pharmacology*
Hypertrophy, Left Ventricular
Male
Myocardial Reperfusion
Myocytes, Cardiac / drug effects*
Perfusion
Pyrroles / pharmacology*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Heptanoic Acids; 0/Pyrroles; 110862-48-1/atorvastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Surgery for severe mitral regurgitation and left ventricular failure: what do we really know?
Next Document:  In vivo effects of myocardial creatine depletion on left ventricular function morphology and lipid m...