Document Detail


Atorvastatin attenuates NF-kappaB activation in trigeminal nucleus caudalis in a rat model of migraine.
MedLine Citation:
PMID:  19733216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nitroglycerin-induced NF-kappaB activation in trigeminal nucleus caudalis is believed to be partly involved in the pathogenesis of migraine. Atorvastatin, an inhibitor of HMG-CoA reductase, is thought to have pleiotropic effects in various neurologic diseases. Moreover, there are several lines of evidences that atorvastatin inhibits NF-kappaB activation in peripheral blood mononuclear cells. Thus, this study aims to explore whether atorvastatin attenuates NF-kappaB activation in trigeminal nucleus caudalis in a nitroglycerin-induced migraine model. A significant increase in nuclear content of p65, an indicator of NF-kappaB activation, was detected in trigeminal nucleus caudalis in rats following injection with nitroglycerin. However, the nitroglycerin-induced NF-kappaB activation in trigeminal nucleus caudalis was attenuated by pretreatment with atorvastatin in a dose-dependent fashion. These results suggest that atorvastatin may be a novel and promising candidate for future treatment or prophylaxis of migraine via attenuating activation of NF-kappaB in trigeminal nucleus caudalis.
Authors:
Zhao Yin; Yannan Fang; Li Ren; Xiaojuan Wang; Aiwu Zhang; Jianwen Lin; Xianliang Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-03
Journal Detail:
Title:  Neuroscience letters     Volume:  465     ISSN:  1872-7972     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-09-23     Completed Date:  2010-01-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  61-5     Citation Subset:  IM    
Affiliation:
Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, No. 58 Zhongshan Road 2, Guangzhou 510080, China. megayin@126.com
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Blotting, Western
Cell Nucleus / drug effects,  metabolism
Disease Models, Animal
Dose-Response Relationship, Drug
Fluorescent Antibody Technique
Heptanoic Acids / administration & dosage,  pharmacology*
Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage,  pharmacology*
Male
Migraine Disorders / chemically induced,  drug therapy*,  metabolism
NF-kappa B / metabolism*
Neoplasm Proteins / metabolism
Neurons / drug effects,  metabolism
Nitroglycerin
Nucleocytoplasmic Transport Proteins / metabolism
Pyrroles / administration & dosage,  pharmacology*
Rats
Rats, Sprague-Dawley
Trigeminal Caudal Nucleus / drug effects*,  metabolism
Chemical
Reg. No./Substance:
0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/NF-kappa B; 0/Neoplasm Proteins; 0/Nucleocytoplasmic Transport Proteins; 0/Pyrroles; 0/p65 oncofetal mRNA transport protein, rat; 110862-48-1/atorvastatin; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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