Document Detail


Atorvastatin administered prior to myocardial infarction in rats improves contractility irrespective of metabolic changes.
MedLine Citation:
PMID:  25223307     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Statins have a beneficial effect after myocardial infarction but the relationship between glucose transporters and their use prior to the event has not yet been studied. We assessed the effects of atorvastatin treatment pre- and post-myocardial infarction on cardiovascular function and GLUT4 in the heart. Wistar-Kyoto rats were treated with atorvastatin, 20 mg/kg or vehicle for 14 days before coronary artery occlusion surgery (MI) or sham surgery. Echocardiographic evaluations were performed 48 hours after MI (Protocol A) and after 7 days (Protocol B), which atorvastatin was also administered. Plasma inflammatory markers and GLUT4 in the heart were also evaluated. Animals were divided into the following groups: C (sham-operated+vehicle), I (MI+vehicle), CAt (sham-operated+atorvastatin) and IAt (MI+atorvastatin). After 48 hours, MI induced higher left ventricular fractional shortening in IAt vs. I (~60%, p=0.036) and the ejection fraction was lower (Protocol A: ~37%; B: ~30%). MI was associated with a rise in plasma membrane GLUT4 after 48 h (~40%, p<0.001) and a reduction in GLUT4 after 7 days (I, 25%; IAt, 49%, p<0.001). Atorvastatin treatment for 48 hours after the infarction did not change GLUT4 expression, and after 7 days it had an additional negative effect on GLUT4 content (~39%, p=0.030). In conclusion, atorvastatin treatment pre- and post-myocardial infarction improved myocardial contractility after 48hr but not 7days, and was not associated with an increase in GLUT4 expression. This article is protected by copyright. All rights reserved.
Authors:
Tatiana Ederich Lehnen; Alexandre Machado Lehnen; Angela Maria Vicente Tavares; Adriane Belló-Klein; Melissa Medeiros Markoski; Ubiratan Fabres Machado; Beatriz Schaan
Related Documents :
25475457 - Osteoprotegerin levels change during stemi and reflect cardiac function.
19081827 - Zebrafish heart regeneration as a model for cardiac tissue repair.
666017 - Lymphatic vessels of the mammalian heart.
16056207 - Morphometric study of atrioventricular orifices of postmortem hearts of adult banglades...
20227777 - Intermittent right bundle branch block development in a patent with acute inferior myoc...
18940287 - Comparison of safety, efficacy, and outcome of successful versus unsuccessful percutane...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-15
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  -     ISSN:  1440-1681     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The Influence of Adnectin Binding on the Extracellular Domain of Epidermal Growth Factor Receptor.
Next Document:  Influences on Grief among Parentally Bereaved Adults.