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Atorvastatin administered prior to myocardial infarction in rats improves contractility irrespective of metabolic changes.
MedLine Citation:
PMID:  25223307     Owner:  NLM     Status:  Publisher    
Statins have a beneficial effect after myocardial infarction but the relationship between glucose transporters and their use prior to the event has not yet been studied. We assessed the effects of atorvastatin treatment pre- and post-myocardial infarction on cardiovascular function and GLUT4 in the heart. Wistar-Kyoto rats were treated with atorvastatin, 20 mg/kg or vehicle for 14 days before coronary artery occlusion surgery (MI) or sham surgery. Echocardiographic evaluations were performed 48 hours after MI (Protocol A) and after 7 days (Protocol B), which atorvastatin was also administered. Plasma inflammatory markers and GLUT4 in the heart were also evaluated. Animals were divided into the following groups: C (sham-operated+vehicle), I (MI+vehicle), CAt (sham-operated+atorvastatin) and IAt (MI+atorvastatin). After 48 hours, MI induced higher left ventricular fractional shortening in IAt vs. I (~60%, p=0.036) and the ejection fraction was lower (Protocol A: ~37%; B: ~30%). MI was associated with a rise in plasma membrane GLUT4 after 48 h (~40%, p<0.001) and a reduction in GLUT4 after 7 days (I, 25%; IAt, 49%, p<0.001). Atorvastatin treatment for 48 hours after the infarction did not change GLUT4 expression, and after 7 days it had an additional negative effect on GLUT4 content (~39%, p=0.030). In conclusion, atorvastatin treatment pre- and post-myocardial infarction improved myocardial contractility after 48hr but not 7days, and was not associated with an increase in GLUT4 expression. This article is protected by copyright. All rights reserved.
Tatiana Ederich Lehnen; Alexandre Machado Lehnen; Angela Maria Vicente Tavares; Adriane Belló-Klein; Melissa Medeiros Markoski; Ubiratan Fabres Machado; Beatriz Schaan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-15
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  -     ISSN:  1440-1681     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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