| Atorvastatin reduces plaque vulnerability in an atherosclerotic rabbit model by altering the 5-lipoxygenase pathway. | |
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MedLine Citation:
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PMID: 20234134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The 5-lipoxygenase catalyzed formation of leukotriene lipid mediators is a mediator for inflammatory response in arteries. The present study investigated the relationship between atorvastatin and the 5-lipoxygenase pathway in an atherosclerotic rabbit model. METHODS: Thirty male New Zealand White Rabbits were randomized into negative control, positive control and atorvastatin groups. At week 4, the rabbits were subjected to carotid balloon-dilation injury or carotid balloon-dilation injury, followed by treatment with atorvastatin. At week 12, all the animals were sacrificed. Plasma lipids, LTD(4), and 15-epi-lipoxin A(4) were measured using the enzymatic endpoint method and ELISA, respectively. RT-PCR was performed to detect the gene expression of 5-lipoxygenase-activating protein and cysLT1R in rabbit carotid arteries. Finally, histological analysis was used to evaluate the pathophysiological changes of rabbit carotid arteries. RESULTS: The results showed atorvastatin markedly lowered serum lipids and LTD(4) levels compared with the control group. Similarly, mRNA expression of 5-lipoxygenase-activating protein and cysLT1R was significantly inhibited by atorvastatin. Decreased carotid plaque instability was evident in atorvastatin-treated animals, as demonstrated by a thickened elastic layer, less neointima hyperplasia and macrophage proliferation. CONCLUSIONS: Atorvastatin may stabilize carotid plaque by regulating the 5-lipoxygenase pathway in atherosclerotic rabbits and delay the progression of atherosclerosis by exerting anti-inflammatory effects. |
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Authors:
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Guangyi Zhou; Song Ge; Dezhi Liu; Gelin Xu; Renliang Zhang; Qin Yin; Wusheng Zhu; Jieli Chen; Xinfeng Liu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-16 |
Journal Detail:
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Title: Cardiology Volume: 115 ISSN: 1421-9751 ISO Abbreviation: Cardiology Publication Date: 2010 |
Date Detail:
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Created Date: 2010-04-08 Completed Date: 2010-07-22 Revised Date: 2010-07-23 |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 221-8 Citation Subset: IM |
Affiliation:
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Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, PR China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticholesteremic Agents / pharmacology* Arachidonate 5-Lipoxygenase / physiology* Carotid Stenosis / blood, genetics*, pathology* Carrier Proteins / genetics* Disease Models, Animal* Elastic Tissue / drug effects, pathology Enzyme-Linked Immunosorbent Assay Gene Expression / drug effects, genetics Heptanoic Acids / pharmacology* Leukotriene D4 / blood Lipids / blood Lipoxins / blood Membrane Proteins / genetics* Muscle, Smooth, Vascular / drug effects, pathology Pyrroles / pharmacology* RNA, Messenger / genetics* Rabbits Receptors, Leukotriene / genetics* Reverse Transcriptase Polymerase Chain Reaction Tunica Intima / drug effects, pathology |
| Chemical | |
Reg. No./Substance:
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0/5-lipoxygenase-activating protein; 0/Anticholesteremic Agents; 0/Carrier Proteins; 0/Heptanoic Acids; 0/Lipids; 0/Lipoxins; 0/Membrane Proteins; 0/Pyrroles; 0/RNA, Messenger; 0/Receptors, Leukotriene; 0/leukotriene D4 receptor; 0/lipoxin A4; 110862-48-1/atorvastatin; 73836-78-9/Leukotriene D4; EC 1.13.11.34/Arachidonate 5-Lipoxygenase |
| Comments/Corrections | |
Comment In:
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Cardiology. 2010;116(1):45-7
[PMID:
20431292
]
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Erratum In:
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Cardiology. 2010 Jul;116(2):116 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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