Document Detail

Atorvastatin reduces plaque vulnerability in an atherosclerotic rabbit model by altering the 5-lipoxygenase pathway.
MedLine Citation:
PMID:  20234134     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The 5-lipoxygenase catalyzed formation of leukotriene lipid mediators is a mediator for inflammatory response in arteries. The present study investigated the relationship between atorvastatin and the 5-lipoxygenase pathway in an atherosclerotic rabbit model. METHODS: Thirty male New Zealand White Rabbits were randomized into negative control, positive control and atorvastatin groups. At week 4, the rabbits were subjected to carotid balloon-dilation injury or carotid balloon-dilation injury, followed by treatment with atorvastatin. At week 12, all the animals were sacrificed. Plasma lipids, LTD(4), and 15-epi-lipoxin A(4) were measured using the enzymatic endpoint method and ELISA, respectively. RT-PCR was performed to detect the gene expression of 5-lipoxygenase-activating protein and cysLT1R in rabbit carotid arteries. Finally, histological analysis was used to evaluate the pathophysiological changes of rabbit carotid arteries. RESULTS: The results showed atorvastatin markedly lowered serum lipids and LTD(4) levels compared with the control group. Similarly, mRNA expression of 5-lipoxygenase-activating protein and cysLT1R was significantly inhibited by atorvastatin. Decreased carotid plaque instability was evident in atorvastatin-treated animals, as demonstrated by a thickened elastic layer, less neointima hyperplasia and macrophage proliferation. CONCLUSIONS: Atorvastatin may stabilize carotid plaque by regulating the 5-lipoxygenase pathway in atherosclerotic rabbits and delay the progression of atherosclerosis by exerting anti-inflammatory effects.
Guangyi Zhou; Song Ge; Dezhi Liu; Gelin Xu; Renliang Zhang; Qin Yin; Wusheng Zhu; Jieli Chen; Xinfeng Liu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-16
Journal Detail:
Title:  Cardiology     Volume:  115     ISSN:  1421-9751     ISO Abbreviation:  Cardiology     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-08     Completed Date:  2010-07-22     Revised Date:  2010-07-23    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  221-8     Citation Subset:  IM    
Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, PR China.
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MeSH Terms
Anticholesteremic Agents / pharmacology*
Arachidonate 5-Lipoxygenase / physiology*
Carotid Stenosis / blood,  genetics*,  pathology*
Carrier Proteins / genetics*
Disease Models, Animal*
Elastic Tissue / drug effects,  pathology
Enzyme-Linked Immunosorbent Assay
Gene Expression / drug effects,  genetics
Heptanoic Acids / pharmacology*
Leukotriene D4 / blood
Lipids / blood
Lipoxins / blood
Membrane Proteins / genetics*
Muscle, Smooth, Vascular / drug effects,  pathology
Pyrroles / pharmacology*
RNA, Messenger / genetics*
Receptors, Leukotriene / genetics*
Reverse Transcriptase Polymerase Chain Reaction
Tunica Intima / drug effects,  pathology
Reg. No./Substance:
0/5-lipoxygenase-activating protein; 0/Anticholesteremic Agents; 0/Carrier Proteins; 0/Heptanoic Acids; 0/Lipids; 0/Lipoxins; 0/Membrane Proteins; 0/Pyrroles; 0/RNA, Messenger; 0/Receptors, Leukotriene; 0/leukotriene D4 receptor; 0/lipoxin A4; 110862-48-1/atorvastatin; 73836-78-9/Leukotriene D4; EC 5-Lipoxygenase
Comment In:
Cardiology. 2010;116(1):45-7   [PMID:  20431292 ]
Erratum In:
Cardiology. 2010 Jul;116(2):116

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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