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Atorvastatin Post-Conditioning Attenuates Myocardial Ischemia Reperfusion Injury Via Inhibiting Endoplasmic Reticulum Stress-Related Apoptosis.
MedLine Citation:
PMID:  25004060     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The present study examined whether atorvastatin, when used for pharmacological post-conditioning, attenuated myocardial ischemia-reperfusion (IR) injury in a manner similar to ischemic post-conditioning, that is, by inhibition of endoplasmic reticulum (ER) stress-related apoptosis. In the present study, markers for myocardial injury, infarct area, and hemodynamics, and indicators of ER stress and apoptosis were compared in ischemic and atorvastatin-induced post-conditioning as a means of evaluating the protective effect of atorvastatin post-conditioning in IR injury and whether, as in ischemic post-conditioning, inhibition of ER stress is involved.Both ischemic and atorvastatin-mediated post-conditioning significantly decreased indications of cardiac damage and reduced serum concentrations of markers for myocardial injury, reduced the infarct area seen at the end of reperfusion, and improved left ventricular systolic function. We found that high dose atorvastatin- and ischemic post-conditioning significantly down-regulated expression of GRP78 and CRT (ER stress markers), expression of CHOP and caspase-12 (markers for ER stress-related apoptosis), and Bax (downstream molecule of CHOP), in the myocardial area-at-risk. Atorvastatin- and ischemic post-conditioning have similar cardioprotective effects in IR injury and inhibit the ER stress-related apoptotic pathway.
Authors:
Jing-Gang Xia; Fei-Fei Xu; Yang Qu; Dan-Dan Song; Hong Shen; Xiu-Hua Liu
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-4
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  -     ISSN:  1540-0514     ISO Abbreviation:  Shock     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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