Document Detail


Atorvastatin modulates matrix metalloproteinase expression, activity, and signaling in abdominal aortic aneurysms.
MedLine Citation:
PMID:  20034937     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Statins may reduce abdominal aortic aneurysm (AAA) progression. We sought to measure how atorvastatin (AT) treatment might modulate matrix metalloproteinase (MMP) expression and/or activity in human AAA. Tissue from human AAAs at surgical repair was obtained from patients who were either not on statins (NST, n = 19) or treated with AT (n = 19). Immunoblots measured expression and zymography measured activity. Expression of most proteins was greater in the central compared with distal AAA region. Matrix metalloproteinase 1, MMP2, MMP3, MMP9, Tissue Inhibitor of Metalloproteinase (TIMP2), TIMP3, TIMP4, or total Sma Mothers Against Decapentaplegia (SMAD2) expression did not differ with treatment. There was a trend toward reduced MMP8 and TIMP1 expression and MMP2 zymographic activity in the AT-treatment group. In contrast, AT-treated samples had significantly reduced MMP13 (P = .02), latent-transforming growth factor (TGF)-beta (P = .02), and phospho-SMAD2 (P = .029) expression than NST-treated samples. We conclude that the AT-mediated decrease in MMP expression and activity reduces TGF-beta signaling in the central region of human AAAs.
Authors:
Morris Schweitzer; Benjamin Mitmaker; Daniel Obrand; Nathan Sheiner; Cherrie Abraham; Stevan Dostanic; Melissa Meilleur; Tomoko Sugahara; Lorraine E Chalifour
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-23
Journal Detail:
Title:  Vascular and endovascular surgery     Volume:  44     ISSN:  1938-9116     ISO Abbreviation:  Vasc Endovascular Surg     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-04-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136421     Medline TA:  Vasc Endovascular Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  116-22     Citation Subset:  IM    
Affiliation:
Department of Endocrinology, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada. morris.schweitzer@mcgill.ca
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MeSH Terms
Descriptor/Qualifier:
Aged
Aorta, Abdominal / drug effects*,  enzymology,  surgery
Aortic Aneurysm, Abdominal / drug therapy*,  enzymology,  surgery
Down-Regulation
Female
Heptanoic Acids / therapeutic use*
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Male
Matrix Metalloproteinases / metabolism*
Phosphorylation
Pyrroles / therapeutic use*
Signal Transduction / drug effects*
Smad2 Protein / metabolism
Tissue Inhibitor of Metalloproteinases / metabolism
Transforming Growth Factor beta / metabolism
Chemical
Reg. No./Substance:
0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrroles; 0/Smad2 Protein; 0/Tissue Inhibitor of Metalloproteinases; 0/Transforming Growth Factor beta; 110862-48-1/atorvastatin; EC 3.4.24.-/Matrix Metalloproteinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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