| Atorvastatin modulates matrix metalloproteinase expression, activity, and signaling in abdominal aortic aneurysms. | |
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MedLine Citation:
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PMID: 20034937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Statins may reduce abdominal aortic aneurysm (AAA) progression. We sought to measure how atorvastatin (AT) treatment might modulate matrix metalloproteinase (MMP) expression and/or activity in human AAA. Tissue from human AAAs at surgical repair was obtained from patients who were either not on statins (NST, n = 19) or treated with AT (n = 19). Immunoblots measured expression and zymography measured activity. Expression of most proteins was greater in the central compared with distal AAA region. Matrix metalloproteinase 1, MMP2, MMP3, MMP9, Tissue Inhibitor of Metalloproteinase (TIMP2), TIMP3, TIMP4, or total Sma Mothers Against Decapentaplegia (SMAD2) expression did not differ with treatment. There was a trend toward reduced MMP8 and TIMP1 expression and MMP2 zymographic activity in the AT-treatment group. In contrast, AT-treated samples had significantly reduced MMP13 (P = .02), latent-transforming growth factor (TGF)-beta (P = .02), and phospho-SMAD2 (P = .029) expression than NST-treated samples. We conclude that the AT-mediated decrease in MMP expression and activity reduces TGF-beta signaling in the central region of human AAAs. |
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Authors:
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Morris Schweitzer; Benjamin Mitmaker; Daniel Obrand; Nathan Sheiner; Cherrie Abraham; Stevan Dostanic; Melissa Meilleur; Tomoko Sugahara; Lorraine E Chalifour |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-23 |
Journal Detail:
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Title: Vascular and endovascular surgery Volume: 44 ISSN: 1938-9116 ISO Abbreviation: Vasc Endovascular Surg Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-21 Completed Date: 2010-04-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136421 Medline TA: Vasc Endovascular Surg Country: United States |
Other Details:
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Languages: eng Pagination: 116-22 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada. morris.schweitzer@mcgill.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aorta, Abdominal / drug effects*, enzymology, surgery Aortic Aneurysm, Abdominal / drug therapy*, enzymology, surgery Down-Regulation Female Heptanoic Acids / therapeutic use* Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Male Matrix Metalloproteinases / metabolism* Phosphorylation Pyrroles / therapeutic use* Signal Transduction / drug effects* Smad2 Protein / metabolism Tissue Inhibitor of Metalloproteinases / metabolism Transforming Growth Factor beta / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrroles; 0/Smad2 Protein; 0/Tissue Inhibitor of Metalloproteinases; 0/Transforming Growth Factor beta; 110862-48-1/atorvastatin; EC 3.4.24.-/Matrix Metalloproteinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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