Document Detail

"Atopy patch tests" in the diagnosis of delayed food hypersensitivity.
MedLine Citation:
PMID:  12012795     Owner:  NLM     Status:  MEDLINE    
The prevalence of atopic diseases is increasing worldwide. Food allergies are the earliest manifestation of atopy. Atopic eczema affects about 18% of infants in the first 2 years of life and the main cause is allergy to multiple foods. A strong association has been shown between atopic eczema and IgE mediated allergy to milk, egg or peanut, but more than two-thirds of patients intolerant to food proteins have no evidence of IgE sensitization to the relevant food protein. Recently, patch testing with proteins has been found to be helpful in diagnosing food allergy in cases where skin prick tests and estimation of specific antibodies have failed. The methodology of atopy patch test (APT) is unstandardized, and contradictory results have been reported. In contrast to the more standardized APT methodology with aeroallergens, the sensitivities and specificities of food allergens can easily be estimated with food challenge tests. With multiallergic children adding of APTs to the skin prick tests and specific antibody estimation tests give more information for planning a wide enough elimination diet to get the skin and gastrointestinal tract symptomless in order to perform the challenge test which remains the only reliable test for food allergy. Standardization of the APT materials and reading procedure will add to the reliability of this new test method.
K Turjanmaa
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Allergie et immunologie     Volume:  34     ISSN:  0397-9148     ISO Abbreviation:  Allerg Immunol (Paris)     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-05-15     Completed Date:  2002-07-12     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0245775     Medline TA:  Allerg Immunol (Paris)     Country:  France    
Other Details:
Languages:  eng     Pagination:  95-7     Citation Subset:  IM    
Department of Dermatology, Tampere University Hospital, P.O. Box 2000, FIN-33521 Tampere.
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MeSH Terms
Allergens / adverse effects,  diagnostic use
Child, Preschool
Dermatitis, Atopic / etiology*
Diagnosis, Differential
Dietary Proteins / adverse effects
Eczema / etiology
Egg Proteins / adverse effects
Food Hypersensitivity / complications,  diagnosis*
Hypersensitivity, Delayed / diagnosis*
Hypersensitivity, Immediate / diagnosis
Milk Hypersensitivity / complications,  diagnosis
Milk Proteins / adverse effects
Patch Tests*
Patient Compliance
Plant Proteins / adverse effects
Sensitivity and Specificity
Triticum / adverse effects
Reg. No./Substance:
0/Allergens; 0/Dietary Proteins; 0/Egg Proteins; 0/Milk Proteins; 0/Plant Proteins

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