Document Detail

Atopy patch test for the diagnosis of food protein-induced enterocolitis syndrome.
MedLine Citation:
PMID:  16846453     Owner:  NLM     Status:  MEDLINE    
Food protein-induced enterocolitis syndrome (FPIES) is thought to be a non-IgE mediated food allergy syndrome. Affected infants typically demonstrate gastrointestinal symptoms after hours after ingestion of the offending food. Traditional allergy testing is not useful for this disorder because tests for food specific IgE are routinely negative. A diagnostic oral food challenge (OFC) is the only method to confirm the diagnosis of FPIES. This prospective study was undertaken to determine whether the atopy patch test (APT) is able to predict the results of the OFC. Nineteen infants with suspected FPIES by clinical history underwent APT to the suspected foods. After APT was performed, subjects underwent OFC to determine whether FPIES was present. The results of APT and OFC were compared and used to calculate sensitivity and specificity of the APT. APT predicted the results of oral food challenges in 28/33 instances. There were 16 cases of FPIES confirmed by oral food challenges. In all 16 cases of FPIES, the APT was positive to the suspected food. However, the APT was positive in five instances where the oral food challenge was negative. All 12 patients with a negative APT had a negative oral food challenge to the suspected food. APT appears to be a promising diagnostic tool for the diagnosis of FPIES.
Matthew I Fogg; Terri A Brown-Whitehorn; Nicholas A Pawlowski; Jonathan M Spergel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  17     ISSN:  0905-6157     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-18     Completed Date:  2006-09-19     Revised Date:  2008-05-28    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  351-5     Citation Subset:  IM    
Division of Allergy and Immunology, Children's Hospital of Philadelphia, PA 19104, USA.
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MeSH Terms
Child, Preschool
Dietary Proteins / adverse effects*,  immunology
Enterocolitis / diagnosis*,  immunology
Food Hypersensitivity / diagnosis*,  immunology
Hypersensitivity, Immediate / diagnosis*,  immunology
Patch Tests / methods*
Prospective Studies
Reg. No./Substance:
0/Dietary Proteins

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