Document Detail

Atopy may be related to exercise-induced bronchospasm in asthma.
MedLine Citation:
PMID:  11972598     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Recent studies suggest that atopy may be associated with exercise-induced bronchospasm (EIB) in asthma. However, it is not clear whether atopy is related to EIB, regardless of airway hyper-responsiveness (AHR) to methacholine, because asthmatic subjects often show AHR to exercise and methacholine simultaneously. OBJECTIVE: To investigate whether atopy is related to EIB in asthmatic subjects, independently of AHR to methacholine. METHODS: Fifty-eight male asthmatic subjects were studied. Initial spirometry was performed. Skin prick test was carried out, using 53 common allergens including mites dust antigen. Atopy score was defined as a sum of mean weal diameters to all allergens tested. Methacholine bronchial provocation testing was performed. Twenty-four hours later, free running test was performed. Positive EIB was defined as a 15% reduction or more in FEV1 from baseline after exercise. RESULTS: All subjects had AHR to methacholine. The degree of AHR to methacholine in asthmatics with EIB was similar to that in asthmatics without EIB. However, atopy score and skin reaction to Dermatophagoides pteronyssinus significantly increased in asthmatics with EIB compared with those without EIB (P < 0.05, respectively). Furthermore, the degree of EIB significantly correlated with atopy score in all subjects (r = 0.35, P < 0.01). This relationship was maintained even after the exclusion of EIB-negative asthmatic subjects. CONCLUSION: Atopy defined as skin test reactivity may contribute to the development of EIB in asthma, independently of AHR to methacholine.
Y I Koh; I S Choi; H Lim
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  32     ISSN:  0954-7894     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-25     Completed Date:  2002-09-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  England    
Other Details:
Languages:  eng     Pagination:  532-6     Citation Subset:  IM    
Division of Allergy, Department of Internal Medicine, Chonnam National University Medical School and Research Institute of Medical Science, Kwangju, Korea.
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MeSH Terms
Antigens, Dermatophagoides
Asthma, Exercise-Induced / diagnosis,  etiology*
Bronchial Hyperreactivity / diagnosis
Bronchial Provocation Tests
Bronchoconstrictor Agents / diagnostic use
Exercise Test
Glycoproteins / diagnostic use
Hypersensitivity, Immediate / complications*,  diagnosis
Methacholine Chloride / diagnostic use
Skin Tests
Reg. No./Substance:
0/Antigens, Dermatophagoides; 0/Bronchoconstrictor Agents; 0/Glycoproteins; 62-51-1/Methacholine Chloride

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