Document Detail

Atopy, lung function, and obstructive airways disease after prenatal exposure to famine.
MedLine Citation:
PMID:  10856314     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Associations have been found between a large head size at birth and atopy, and between low birth weight and obstructive airways disease. A study was undertaken of people born around the time of the Dutch famine in 1944-5 to determine the effects of maternal malnutrition during specific periods of gestation on the prevalence of obstructive airways disease and atopy. METHODS: Nine hundred and twelve people aged about 50, born at term between November 1943 and February 1947 in Amsterdam, were asked about their medical history. Lung function was measured in 733 and serum concentrations of total IgE and specific IgE against mite, pollen and cat were measured in 726. Those exposed in late, mid, and early gestation (exposed participants) were compared with those born before or conceived after the famine (non-exposed participants). RESULTS: Exposure to famine during gestation affected neither the concentrations of total or specific IgE nor lung function values. The prevalence of obstructive airways disease was increased in people exposed to famine in mid gestation (odds ratio adjusted for sex 1.7, 95% confidence interval (CI) 1.1 to 2.6) and tended to be higher in those exposed in early gestation (odds ratio 1.5, 95% CI 0. 9 to 2.6). CONCLUSIONS: The observed increase in the prevalence of obstructive airways disease in people exposed to famine in mid and early gestation was not parallelled by effects on IgE concentrations or lung function. The link between exposure to famine in mid and early gestation and obstructive airways disease in adulthood suggests that fetal lungs can be permanently affected by nutritional challenges during periods of rapid growth.
C E Lopuhaä; T J Roseboom; C Osmond; D J Barker; A C Ravelli; O P Bleker; J S van der Zee; J H van der Meulen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thorax     Volume:  55     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-07-21     Completed Date:  2000-07-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  555-61     Citation Subset:  IM    
Department of Pulmonology, Academic Medical Center, University of Amsterdam, The Netherlands.
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MeSH Terms
Birth Weight
Cohort Studies
Embryonic and Fetal Development
Food Supply
Forced Expiratory Volume / physiology
Hypersensitivity / epidemiology
Immunoglobulin E / blood
Lung Diseases, Obstructive / epidemiology*
Middle Aged
Netherlands / epidemiology
Nutrition Disorders / epidemiology*
Odds Ratio
Pregnancy Complications / epidemiology*
Prenatal Exposure Delayed Effects*
Vital Capacity / physiology
Reg. No./Substance:
37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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