Document Detail


Atopic status of an adult population with active and inactive tuberculosis.
MedLine Citation:
PMID:  11332297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The rise in allergic disorders over the past three decades has been suggested to be related to the decrease in infectious diseases. Recently, a negative association between tuberculin responses and atopic disorders has also been reported. We planned to investigate the effect of natural exposure to Mycobacterium tuberculosis on atopic status in patients with active tuberculosis and to compare the findings with the data of patients with inactive disease. A total of 97 subjects were divided into two groups. Group 1, patients with proven active pulmonary tuberculosis (n = 66); group 2, subjects who had a history of previous tuberculous disease, with negative bacteriologic studies and no clinical and/or roentgenographic evidence of current disease (n = 31). Current history of allergic diseases was recorded by a physician with the use of a questionnaire adapted from the European Community Respiratory Health Survey (ECRHS), and skin-prick tests (SPTs) were performed using a standardized panel. Total IgE and Phadiatop were measured by the Pharmacia uniCAP system. The rate of one or more positive SPTs was significantly lower in the patients with active tuberculosis than the inactive group (15% versus 48.4%, p < 0.001). The current history of atopic diseases was 7.6% and 29% in the active and inactive tuberculosis groups, respectively (p = 0.002). The rate of positive skin tests to inhalant allergens in patients with inactive disease was higher than the rate of healthy adult Turkish people (48.4% versus 25%, p = 0.001). Geometric mean of total IgE levels were lower in patients with inactive disease than patients with active pulmonary tuberculosis (74.97 kU/L versus 106.3 kU/L, p = 0.05). The ratios of Phadiatop positivity were 21% and 38.7% in the active and inactive tuberculosis groups, respectively (p = 0.008). We found lower atopy rates in patients with active pulmonary tuberculosis than subjects with inactive disease. Although our data support the hypothesis that M. tuberculosis may prevent the development of atopic disorders by inducing the production of cytokines antagonistic to Th2 development, we believe prospective and experimental studies are needed before attributing a direct cause-effect link to this association.
Authors:
D Mungan; B A Sin; G Celik; O U Gürkan; T Acican; Z Misirligil
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Allergy and asthma proceedings : the official journal of regional and state allergy societies     Volume:  22     ISSN:  1088-5412     ISO Abbreviation:  Allergy Asthma Proc     Publication Date:    2001 Mar-Apr
Date Detail:
Created Date:  2001-05-02     Completed Date:  2001-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9603640     Medline TA:  Allergy Asthma Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  87-91     Citation Subset:  IM    
Affiliation:
Department of Allergic Diseases, University of Ankara, Faculty of Medicine, Ankara, Türkiye.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Allergens / immunology
Confounding Factors (Epidemiology)
Female
Humans
Hypersensitivity, Immediate / epidemiology,  immunology*
Immunoglobulin E / blood
Male
Prevalence
Questionnaires
Risk Factors
Skin Tests
Tuberculin / immunology
Tuberculosis / epidemiology,  immunology*
Turkey / epidemiology
Chemical
Reg. No./Substance:
0/Allergens; 0/Tuberculin; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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