Document Detail

Atopic dermatitis: correlation between non-damaged skin barrier function and disease activity.
MedLine Citation:
PMID:  22607284     Owner:  NLM     Status:  In-Data-Review    
Background  Atopic dermatitis (AD) is a chronic dermatosis, predominant in childhood, characterized by pruritus and eczematous-type lesions with xerosis as the prominent clinical sign. Objectives  To analyze the correlation between biophysical measurements of skin barrier function and other assessment criteria of clinical severity according to Rajka and Langeland's criteria. Methods  Biophysical measurements [transepidermal water loss (TEWL) and corneometry] were obtained from 120 patients with the diagnosis of AD. Serum levels of IgE were also evaluated. Results  A significant correlation between corneometry, TEWL, and clinical severity of AD was found. Data showed an inverse correlation between corneometry, TEWL, and AD severity, and a significant difference (P < 0.001) between mean of corneometry and TEWL and AD severity (mild, moderate, and severe). As for IgE levels, corneometry had significant negative correlation, in contrast with TEWL, which showed a significant positive correlation (P < 0.001). Conclusion  Biophysical measurements of skin barrier in non-lesional skin of AD may work as an evaluation factor for AD severity.
Flavia A S Addor; Roberto Takaoka; Evandro A Rivitti; Valeria Aoki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of dermatology     Volume:  51     ISSN:  1365-4632     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  672-6     Citation Subset:  IM    
Copyright Information:
© 2012 The International Society of Dermatology.
Department of Dermatology, University of Sao Paulo Medical School, São Paulo -SP, Brazil.
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