Document Detail

Atopic dermatitis and allergy in children: a dynamic relationship.
MedLine Citation:
PMID:  18706963     Owner:  NLM     Status:  MEDLINE    
Atopic dermatitis (AD) is the most common chronic skin disease in children. The defective barrier function of the skin in patients with AD allows foreign proteins to enter the body and interact with components of the innate and adaptive immune systems. The immune response characteristic of AD is complex with the majority of patients making IgE in response to ingested and/or inhaled antigens. Although IgE-mediated mechanisms may represent initial immune responses, they are only one element of a biphasic inflammatory response. Identifying the role of specific allergens in a patient's skin disease is critical yet difficult because diagnostic tests are often not able to distinguish asymptomatic sensitization from true clinical allergy.
Laurie A Lee
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Publication Detail:
Type:  Journal Article     Date:  2008-07-30
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  46 Suppl 10     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-20     Completed Date:  2009-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  S6-S11     Citation Subset:  IM    
Pediatric Allergy and Immunology, Duke University Medical Center, Box 3559, Durham, NC 27710, USA.
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MeSH Terms
Allergens / immunology*
Child, Preschool
Dermatitis, Atopic / diagnosis,  etiology*,  immunology*,  prevention & control
Dermatitis, Contact / complications,  diagnosis*,  immunology
Diagnosis, Differential
Food Hypersensitivity / complications,  diagnosis*,  immunology
Immunoglobulin E / blood,  immunology
Reg. No./Substance:
0/Allergens; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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