Document Detail

Atopic cough-like cough hypersensitivity caused by active sensitization with protein fraction of Aspergillus restrictus strain A-17.
MedLine Citation:
PMID:  17951087     Owner:  NLM     Status:  MEDLINE    
We examined the sensitivity of the cough reflex to inhaled citric acid in guinea pigs that had been actively sensitized with the protein fraction of Aspergillus restrictus strain A-17. The number of coughs elicited by an aerosol of 5% citric acid was significantly increased in the sensitized group compared to the non-sensitized group. The number of citric-acid-induced coughs in sensitized guinea pigs was dose-dependently and significantly reduced to the level in non-sensitized guinea pigs when animals were pretreated with fexofenadine, a selective histamine H1 receptor antagonist, 60min before citric acid inhalation. The bronchial responsiveness to inhaled methacholine or histamine in the sensitized group was not significantly heightened compared to the non-sensitized group. These results suggest that active sensitization with the protein fraction of A. restrictus by itself, that is without subsequent allergen challenge, enhances the excitability of cough receptors to tussive stimuli, and the physiologic features of this animal model are consistent with those of atopic cough.
Junzo Kamei; Yoshiki Takahashi; Takeshi Itabashi; Shunsuke Hayashi; Ken-ichi Kawai
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Publication Detail:
Type:  Journal Article     Date:  2007-09-21
Journal Detail:
Title:  Pulmonary pharmacology & therapeutics     Volume:  21     ISSN:  1094-5539     ISO Abbreviation:  Pulm Pharmacol Ther     Publication Date:  2008  
Date Detail:
Created Date:  2008-03-05     Completed Date:  2008-08-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9715279     Medline TA:  Pulm Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  356-9     Citation Subset:  IM    
Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo 142-8501, Japan.
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MeSH Terms
Administration, Inhalation
Antigens, Fungal / immunology*
Antitussive Agents / administration & dosage,  pharmacology
Aspergillus / immunology*
Bronchial Hyperreactivity / chemically induced,  immunology,  physiopathology
Bronchoconstrictor Agents / administration & dosage,  pharmacology
Citric Acid
Cough / chemically induced,  immunology*,  physiopathology
Dose-Response Relationship, Drug
Fungal Proteins / immunology*
Guinea Pigs
Histamine / administration & dosage,  pharmacology
Histamine Agonists / administration & dosage,  pharmacology
Histamine H1 Antagonists, Non-Sedating / administration & dosage,  pharmacology
Methacholine Chloride / administration & dosage,  pharmacology
Respiratory Hypersensitivity / chemically induced,  immunology*,  physiopathology
Terfenadine / administration & dosage,  analogs & derivatives,  pharmacology
Reg. No./Substance:
0/Antigens, Fungal; 0/Antitussive Agents; 0/Bronchoconstrictor Agents; 0/Fungal Proteins; 0/Histamine Agonists; 0/Histamine H1 Antagonists, Non-Sedating; 138452-21-8/fexofenadine; 50679-08-8/Terfenadine; 51-45-6/Histamine; 62-51-1/Methacholine Chloride; 77-92-9/Citric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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