| Atopaxar. A novel player in antiplatelet therapy? | |
| | |
MedLine Citation:
|
PMID: 22859265 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Atopaxar, also known as E 5555 is a novel reversible protease-activated receptor-1 (PAR-1) thrombin receptor antagonist. To date, Atopaxar has been investigated in phase II trials with focus on safety and tolerability in patients with acute coronary syndromes or stable coronary artery disease on top of standard antiplatelet therapy. Atopaxar was generally well tolerated, however a rise in liver enzymes and prolongation of the QTcF interval were observed. The data suggest, that atopaxar administration may promote some minor bleeding complications, but does not seem to significantly increase the risk of major bleeding. Although not powered for efficacy, the currently available data suggest potential benefits in patients at high risk for recurrent ischemic events on top of standard antiplatelet therapy. In conclusion, more studies (e.g. phase III) are needed to evaluate efficacy and safety of atopaxar. |
| | |
Authors:
|
T Wurster; A E May |
Related Documents
:
|
23563735 - Treatment of the residual cavity during hepatic hydatidosis surgery: a cohort study of ... 21385145 - An indirect comparison, via enoxaparin, of rivaroxaban with dabigatran in the preventio... 9498025 - Long-term follow-up of eczema patients treated with cyclosporine. 23381015 - De novo portal vein thrombosis in virus-related cirrhosis: predictive factors and long-... 21930995 - Predictors of healing and functional outcome following transmetatarsal amputations. 12811665 - Gastrointestinal symptoms are more intense in morbidly obese patients. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Hämostaseologie Volume: 32 ISSN: 0720-9355 ISO Abbreviation: Hamostaseologie Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-08-03 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8204531 Medline TA: Hamostaseologie Country: Germany |
Other Details:
|
Languages: eng Pagination: 228-33 Citation Subset: IM |
Affiliation:
|
Prof. Andreas May, University Hospital Tübingen - Cardiology, Otfried-Müller-Str. 10, 72076 Tübingen, Germany, Tel. +49/(0)7071/2983160; Fax +49/(0)7071/294473, E-mail: andreas.may@med.uni-tuebingen.de. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ptaquiloside-induced early-stage urothelial lesions show increased cell proliferation and intact ?-c...
Next Document: Carbon dioxide as a carbon source in organic transformation: carbon-carbon bond forming reactions by...