Document Detail

Atmospheric pressure laser desorption/chemical ionization mass spectrometry: a new ionization method based on existing themes.
MedLine Citation:
PMID:  11921247     Owner:  NLM     Status:  MEDLINE    
We have designed and constructed an atmospheric pressure laser desorption/chemical ionization (AP-LD/CI) source that utilizes a laser pulse to desorb intact neutral molecules, followed by chemical ionization via reagent ions produced by a corona discharge. This source employs a heated capillary atmospheric pressure inlet coupled to a quadrupole ion trap mass spectrometer and allows sampling under normal ambient air conditions. Preliminary results demonstrate that this technique provides approximately 150-fold increase in analyte ions compared to the ion population generated by atmospheric pressure infrared matrix-assisted laser desorption/ionization (AP-IR-MALDI).
Joshua J Coon; Kevin J McHale; W W Harrison
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Rapid communications in mass spectrometry : RCM     Volume:  16     ISSN:  0951-4198     ISO Abbreviation:  Rapid Commun. Mass Spectrom.     Publication Date:  2002  
Date Detail:
Created Date:  2002-03-28     Completed Date:  2002-04-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8802365     Medline TA:  Rapid Commun Mass Spectrom     Country:  England    
Other Details:
Languages:  eng     Pagination:  681-5     Citation Subset:  IM    
Copyright Information:
Copyright 2002 John Wiley & Sons, Ltd.
Department of Chemistry, University of Florida, Gainesville, FL 32611, USA.
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MeSH Terms
Air Pressure
Indicators and Reagents
Reserpine / analysis
Spectrometry, Mass, Electrospray Ionization / instrumentation*
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Spiperone / analysis
Grant Support
Reg. No./Substance:
0/Indicators and Reagents; 0/Solvents; 50-55-5/Reserpine; 749-02-0/Spiperone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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