| Formation of carcinogens indoors by surface-mediated reactions of nicotine with nitrous acid, leading to potential thirdhand smoke hazards. | |
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MedLine Citation:
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PMID: 20142504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study shows that residual nicotine from tobacco smoke sorbed to indoor surfaces reacts with ambient nitrous acid (HONO) to form carcinogenic tobacco-specific nitrosamines (TSNAs). Substantial levels of TSNAs were measured on surfaces inside a smoker's vehicle. Laboratory experiments using cellulose as a model indoor material yielded a > 10-fold increase of surface-bound TSNAs when sorbed secondhand smoke was exposed to 60 ppbv HONO for 3 hours. In both cases we identified 1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal, a TSNA absent in freshly emitted tobacco smoke, as the major product. The potent carcinogens 4-(methylnitrosamino)-1-(3-pyridinyl)-1-butanone and N-nitroso nornicotine were also detected. Time-course measurements revealed fast TSNA formation, with up to 0.4% conversion of nicotine. Given the rapid sorption and persistence of high levels of nicotine on indoor surfaces-including clothing and human skin-this recently identified process represents an unappreciated health hazard through dermal exposure, dust inhalation, and ingestion. These findings raise concerns about exposures to the tobacco smoke residue that has been recently dubbed "thirdhand smoke." Our work highlights the importance of reactions at indoor interfaces, particularly those involving amines and NO(x)/HONO cycling, with potential health impacts. |
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Authors:
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Mohamad Sleiman; Lara A Gundel; James F Pankow; Peyton Jacob; Brett C Singer; Hugo Destaillats |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-02-08 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 107 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-14 Completed Date: 2010-05-14 Revised Date: 2010-10-14 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 6576-81 Citation Subset: IM |
Affiliation:
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Indoor Environment Department, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 70-108B, Berkeley, CA 94720, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adsorption Carcinogens / chemistry* Cellulose / chemistry Chemistry / methods Chromatography, Gas / methods Gases Humans Kinetics Nicotine / chemistry* Nitrogen Oxides / chemistry Nitrous Acid / chemistry* Surface Properties Tandem Mass Spectrometry / methods Tobacco Tobacco Smoke Pollution* |
| Grant Support | |
ID/Acronym/Agency:
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DA012393/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 0/Gases; 0/Nitrogen Oxides; 0/Tobacco Smoke Pollution; 54-11-5/Nicotine; 7782-77-6/Nitrous Acid; 9004-34-6/Cellulose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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