| Atlas-Based Versus Individual-Based Fiber Tracking of the Corpus Callosum in Patients with Multiple Sclerosis: Reliability and Clinical Correlations. | |
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MedLine Citation:
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PMID: 22092885 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: In multiple sclerosis (MS), the presence of lesions and normal-appearing white matter damage may affect the reliability of diffusion tensor (DT) magnetic resonance imaging (MRI)-based tractography. We compared the performance of an individual-based method for corpus callosum (CC) fiber tracking in MS with those of two atlas-based methods. METHODS: Brain DT MRI scans were acquired from 35 patients with MS and 18 age-matched healthy volunteers (HV). DT-derived metrics from the CC-the mean diffusivity (MD) and fractional anisotropy (FA)-were calculated using an individual-based and two atlas-based methods with different types of subject registration (linear and nonlinear) to a CC atlas. Customized termination criteria were applied to stop the tracking algorithm when using the individual-based method. RESULTS: All the methods were able to distinguish between MS patients and HV. Using the individual-based method, stronger relationships were found between CC DT-derived metrics and the subjects' clinical condition. CONCLUSION: CC DT tractography using an individual-based method is more sensitive than the atlas-based ones to tract-specific alterations related to MS disability. An atlas-based method with nonlinear registration can be a valid alternative when an automated postprocessing is warranted, such as in the case of high volumes of data. J Neuroimaging 2011;XX:1-10. |
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Authors:
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Maria Marcella Laganà; Antonia Ceccarelli; Maria Giulia Preti; Chiara Venturelli; Maria Pia Sormani; Rosella Cavarretta; Giuseppe Baselli; Pietro Cecconi; Domenico Caputo; Marco Rovaris |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-13 |
Journal Detail:
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Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: - ISSN: 1552-6569 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 American Society of Neuroimaging. |
Affiliation:
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From Fondazione Don C. Gnocchi, Italy (MML, AC, MGP, RC, PC, DC, MR); Department of Biomedical Engineering, Politecnico di Milano, Milan, Italy (MGP, CV, GB); and Unit of Biostatistics, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy (MPS). |
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