| Is the 'athlete's heart' arrhythmogenic? Implications for sudden cardiac death. | |
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MedLine Citation:
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PMID: 21510716 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Whether the ventricular hypertrophic response to athletic training can predispose to fatal ventricular dysrhythmias via mechanisms similar to that of pathological hypertrophy is controversial. This review examines current information regarding the metabolic and electrophysiological differences between the myocardial hypertrophy of heart disease and that associated with athletic training. In animal studies, the biochemical and metabolic profile of physiological hypertrophy from exercise training can largely be differentiated from that of pathological hypertrophy, but it is not clear if the former might represent an early stage in the spectrum of the latter. Information as to whether the electrical remodelling of the athlete's heart mimics that of patients with heart disease, and therefore serves as a substrate for ventricular dysrhythmias, is conflicting. If ventricular remodelling associated with athletic training can trigger fatal dysrhythmias, such cases are extraordinarily rare and thereby impossible to investigate by any standard experimental approach. Greater insight into this issue may come from a better understanding of the electrical responses to both acute bouts of exercise and chronic training in young athletes. |
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Authors:
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Thomas Rowland |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Sports medicine (Auckland, N.Z.) Volume: 41 ISSN: 1179-2035 ISO Abbreviation: Sports Med Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-22 Completed Date: 2011-08-15 Revised Date: 2013-05-16 |
Medline Journal Info:
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Nlm Unique ID: 8412297 Medline TA: Sports Med Country: New Zealand |
Other Details:
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Languages: eng Pagination: 401-11 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Baystate Medical Center, Springfield, Massachusetts 01199, USA. Thomas.rowland@bhs.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arrhythmias, Cardiac
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etiology* Athletes* Cardiomegaly / etiology Cardiomyopathy, Hypertrophic / complications*, diagnosis, physiopathology Death, Sudden, Cardiac / etiology* Electrophysiological Phenomena Exercise / physiology* Humans Sports / physiology* Ventricular Remodeling / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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