Document Detail

Atherothrombosis and plaque heterology: different location or a unique disease?
MedLine Citation:
PMID:  18580067     Owner:  NLM     Status:  MEDLINE    
Formation of unstable plaques frequently results in atherothrombosis, the major cause for ischaemic stroke, myocardial infarction and peripheral arterial disease. Patients who have symptomatic thrombosis in one vascular bed are at increased risk of disease in other beds. However, the development of the disease in carotid, coronary and peripheral arteries may have different pathophysiology suggesting that more complex treatment protocols may have to be designed to reduce plaque development at different locations. In this review we describe the known risk factors, compare the developmental features of coronary and carotid plaque development and determine their association with end-point ischaemic events. Differences are also seen in the genetic contribution to plaque development as well as in the deregulation of gene and protein expression and cellular signal transduction activity of active cells in regions susceptible to thrombosis. Differences between carotid and coronary artery plaque development might help to explain the differences in anatomopathological appearance and risk of rupture.
M Slevin; Q Wang; M Angels Font; A Luque; Oriol Juan-Babot; J Gaffney; P Kumar; S Kumar; L Badimon; J Krupinski
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Publication Detail:
Type:  Comparative Study; Journal Article; Review     Date:  2008-06-26
Journal Detail:
Title:  Pathobiology : journal of immunopathology, molecular and cellular biology     Volume:  75     ISSN:  1423-0291     ISO Abbreviation:  Pathobiology     Publication Date:  2008  
Date Detail:
Created Date:  2008-06-26     Completed Date:  2008-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007504     Medline TA:  Pathobiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  209-25     Citation Subset:  IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester, UK.
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MeSH Terms
Aged, 80 and over
Carotid Artery Diseases / blood,  genetics,  pathology*
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Coronary Artery Disease / blood,  genetics,  pathology*
Middle Aged
Rupture, Spontaneous
Tunica Intima / pathology
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL

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