| Atherothrombosis and plaque heterology: different location or a unique disease? | |
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MedLine Citation:
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PMID: 18580067 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Formation of unstable plaques frequently results in atherothrombosis, the major cause for ischaemic stroke, myocardial infarction and peripheral arterial disease. Patients who have symptomatic thrombosis in one vascular bed are at increased risk of disease in other beds. However, the development of the disease in carotid, coronary and peripheral arteries may have different pathophysiology suggesting that more complex treatment protocols may have to be designed to reduce plaque development at different locations. In this review we describe the known risk factors, compare the developmental features of coronary and carotid plaque development and determine their association with end-point ischaemic events. Differences are also seen in the genetic contribution to plaque development as well as in the deregulation of gene and protein expression and cellular signal transduction activity of active cells in regions susceptible to thrombosis. Differences between carotid and coronary artery plaque development might help to explain the differences in anatomopathological appearance and risk of rupture. |
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Authors:
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M Slevin; Q Wang; M Angels Font; A Luque; Oriol Juan-Babot; J Gaffney; P Kumar; S Kumar; L Badimon; J Krupinski |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review Date: 2008-06-26 |
Journal Detail:
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Title: Pathobiology : journal of immunopathology, molecular and cellular biology Volume: 75 ISSN: 1423-0291 ISO Abbreviation: Pathobiology Publication Date: 2008 |
Date Detail:
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Created Date: 2008-06-26 Completed Date: 2008-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007504 Medline TA: Pathobiology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 209-25 Citation Subset: IM |
Copyright Information:
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Copyright 2008 S. Karger AG, Basel. |
Affiliation:
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School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Carotid Artery Diseases / blood, genetics, pathology* Cholesterol, HDL / blood Cholesterol, LDL / blood Coronary Artery Disease / blood, genetics, pathology* Female Humans Male Middle Aged Rupture, Spontaneous Tunica Intima / pathology |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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