| Atherosclerotic plaques induced by marble-burying behavior are stabilized by exercise training in experimental atherosclerosis. | |
| | |
MedLine Citation:
|
PMID: 20579750 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: We assessed the hypothesis whether behavioral stress may affect the development of atherosclerosis and whether regular exercise training may influence the composition of atherosclerotic plaques in apolipoprotein (apo) E-deficient mice. METHODS: Atherosclerosis was induced in apo E-deficient mice fed a high fat diet. Exercise training (45min swimming, 3 times/week) was conducted, and behavioral stress was provoked by glass marble-burying procedure. Mice were treated with marble-burying, marble-burying behavior plus swimming training, and swimming alone over 8weeks. RESULTS: Exercise training decreased the atherosclerotic lesions, but marble-burying behavior increased the lesions. The plaques containing macrophage accumulation with intercellular adhesion molecule-1 (ICAM-1) expression associated with reduced collagen contents were induced in the mice treated with marble-burying. However, ICAM-1 expression was suppressed and collagen contents were reversed in the mice that received marble-burying behavior plus exercise training. In addition, exercise alone and concomitant exercise training reduced the superoxide production in aortic walls, shown by dihydroethidium staining, compared with that in mice with marble-burying behavior alone. There were no significant differences in the serum lipids profiles among the groups. CONCLUSIONS: Behavioral stress increased the atherosclerotic lesions and induced the adhesion molecule expression with superoxide production on the lesions in apo E-deficient mice. Exercise training may stabilize plaque lesions induced by marble-burying behavior in this animal model. |
| | |
Authors:
|
Kana Shimada; Yu Mikami; Toshinori Murayama; Masayuki Yokode; Masatoshi Fujita; Toru Kita; Chiharu Kishimoto |
Publication Detail:
|
Type: Journal Article Date: 2010-06-26 |
Journal Detail:
|
Title: International journal of cardiology Volume: 151 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-09-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 284-9 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Oestradiol supplement minimises coronary occlusion-induced myocardial infarction and ventricular dys...
Next Document: Usefulness of the MOSAIC (measurement of stenosis by aliasing coronary flow) method using transthora...