Document Detail

Atherosclerotic plaque rupture: a fatigue process?
MedLine Citation:
PMID:  11090294     Owner:  NLM     Status:  MEDLINE    
The mechanism of atherosclerotic plaque rupture is not known. Current theories focus on the acute triggers of plaque rupture and myocardial infarction such as increased shear or circumferential stress, rupture of the vasa vasorum and vasospasm. We hypothesize that a critical mechanism causing plaque rupture is fatigue failure, the catastrophic rupture of a material following exposure to high-cycle, low-amplitude repetitive stress. Comparisons between material fatigue and plaque rupture demonstrate that this hypothesis is consistent with known physiologic and epidemiologic data on plaque rupture.
A J Bank; A Versluis; S M Dodge; W H Douglas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medical hypotheses     Volume:  55     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-01-08     Completed Date:  2001-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  480-4     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Harcourt Publishers Ltd.
Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55102, USA.
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MeSH Terms
Arteriosclerosis / pathology*
Comment In:
Med Hypotheses. 2002 Apr;58(4):359-60   [PMID:  12027533 ]

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