| Atherosclerotic plaque pathohistology and classification with high-resolution MRI. | |
| | |
MedLine Citation:
|
PMID: 20810025 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
METHODS: Eight consecutive patients (five males, mean age 67·4 years) who were recruited into our study had high-grade stenosis or occlusion of carotid artery and FA (70 to 100%). Four patients accepted carotid endarterectomy and others underwent FA prosthetic reconstruction. RESULTS: The high level of accuracy was shown in classification of the plaque type. The sections of plaques detected by MRI were classified as follows: 12 (22·2%) were modified American Heart Association (AHA) type III, 11 (20·4%) were type IV-V, 26 (48·2%) were type VI and 5 (9·3%) were type VII. According to the histological observations, the overall accurate rate by MRI showed a high level accuracy of 90·7% (49/54). Immunohistochemistry of cellular components in plaque shoulder demonstrated that CD68-positive macrophages were strongly dominated along the arterial wall. Reduced expression of smooth muscle actin (SMA)-positive smooth muscle cells were detected in the fibrous cap of atheroma. CD31 stain showed the increased presence of CD31-positive neomicrovessels. CONCLUSIONS: Atherosclerosis is a systematic disease that can involve whole body vascular beds. Non-invasive high-resolution MRI will provide useful information in morphological studies of the arterial walls and classification of the plaque type. |
| | |
Authors:
|
Tianli Gao; Xiaofen He; Wei Yu; Zhuo Zhang; Yongjun Wang |
Related Documents
:
|
17457865 - Carotid plaque classification: defining the certainty with which plaque components can ... 10613545 - Preliminary cladistic analysis of genera of the cestode order trypanorhyncha diesing, 1... 20829705 - Carotid plaques in transient ischemic attack and stroke patients: one-year follow-up st... 10831525 - In vivo magnetic resonance evaluation of atherosclerotic plaques in the human thoracic ... 15504715 - Late onset hyperekplexia. 19196635 - Superficial siderosis revealed by isolated cognitive impairment. |
Publication Detail:
|
Type: Journal Article Date: 2010-08-31 |
Journal Detail:
|
Title: Neurological research Volume: 33 ISSN: 1743-1328 ISO Abbreviation: Neurol. Res. Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-04-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7905298 Medline TA: Neurol Res Country: England |
Other Details:
|
Languages: eng Pagination: 325-30 Citation Subset: IM |
Affiliation:
|
Department of Neurology, Capital Medical University, Beijing Anzhen Hospital, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Motor unit number estimation in transected peripheral nerves.
Next Document: Granulocyte colony-stimulating factor enhances cellular proliferation and motor function recovery on...