Document Detail


Atherosclerotic plaque composition assessed by virtual histology intravascular ultrasound and cerebral embolization after carotid stenting.
MedLine Citation:
PMID:  20655687     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Previous studies have investigated the predictive value of clinical and morphologic parameters for distal embolization during carotid interventions. The composition of the atherosclerotic plaque, using virtual histology intravascular ultrasound (VH-IVUS) imaging obtained with an IVUS catheter that is advanced through the lesion after a filter has been placed distally, has not been evaluated as a marker for cerebral embolization. The purpose of this study was to assess the relationship between atherosclerotic plaque composition determined with VH-IVUS and the occurrence of cerebral embolization after carotid artery stenting (CAS).
METHODS: During a 10-month period, 24 patients undergoing CAS procedures using a filter device for embolic protection were prospectively evaluated. All patients underwent VH-IVUS exams at the time of the intervention, transcranial Doppler (TCD) monitoring during CAS, and pre- and 24-hour postprocedural diffusion-weighted magnetic resonance imaging (DW-MRI) exams. Using VH-IVUS, plaque components were characterized as fibrotic, fibrofatty, dense calcium, and necrotic core. The frequency of Doppler-detected microembolic signals (MES) during CAS and the incidence and location of acute postprocedural embolic lesions detected with DW-MRI were assessed to determine cerebral embolization. Univariate and correlation analyses were used to assess the association between plaque composition and frequency of cerebral embolization.
RESULTS: No periprocedural transient ischemic attacks, strokes, or deaths occurred within 30 days. Seventeen patients (71%) demonstrated new acute cerebral emboli in DW-MRI. Of these, all revealed ipsilateral lesions and 12 (50%) had contralateral lesions. For the entire study group, the median number of ipsilateral DW-MRI lesions was 1 (range, 0 to 3), and TCD MES counts were 227 (interquartile range, 143-315). Volumetric VH-IVUS analysis revealed that there was a trend for larger median dense calcium volume in patients with ipsilateral subclinical cerebral embolism detected with DW-MRI (33.2±24.5 mm3 vs 11.4±6.1 mm3; P=.08). Scatter plots of plaque components revealed statistically significant correlation between fibrofatty plaque volume (Spearman r=0.49; P=.016) and number of new ipsilateral lesions in DW-MRI. Degree of cerebral embolization during CAS measured with TCD correlated with plaque burden, necrotic core, fibrofatty, and fibrous volumes.
CONCLUSIONS: Plaque composition, as determined by VH-IVUS, only weakly correlates with the degree of cerebral embolization after carotid stenting. Specifically, there is a trend for larger dense calcium volume in patients with distal embolization. Of note, the proportion of necrotic core, which has traditionally been considered the main component of a vulnerable or unstable plaque, is not definitely associated with subclinical cerebral embolization after CAS when a filter device for embolic protection is used. The role of VH-IVUS in evaluating plaque composition during CAS remains unestablished and warrants further investigation.
Authors:
Carlos H Timaran; Eric B Rosero; Andres E Martinez; Adriana Ilarraza; J Gregory Modrall; G Patrick Clagett
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-07-23
Journal Detail:
Title:  Journal of vascular surgery     Volume:  52     ISSN:  1097-6809     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-05     Completed Date:  2010-12-10     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1188-94     Citation Subset:  IM    
Copyright Information:
Published by Mosby, Inc.
Affiliation:
Division of Vascular and Endovascular Surgery, Department of Surgery, Veterans Affairs North Texas Health Care System, University of Texas Southwestern Medical Center, Dallas, TX 75390-9157, USA. carlos.timaran@utsouthwestern.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Angioplasty, Balloon / adverse effects,  instrumentation*
Carotid Artery Diseases / pathology,  therapy*,  ultrasonography*
Chi-Square Distribution
Diffusion Magnetic Resonance Imaging
Embolic Protection Devices
Humans
Intracranial Embolism / etiology*,  pathology,  prevention & control,  ultrasonography
Lipids / analysis
Male
Middle Aged
Necrosis
Predictive Value of Tests
Prospective Studies
Risk Assessment
Risk Factors
Stents*
Texas
Time Factors
Treatment Outcome
Ultrasonography, Doppler, Transcranial
Ultrasonography, Interventional*
Chemical
Reg. No./Substance:
0/Lipids
Comments/Corrections
Comment In:
J Vasc Surg. 2010 Nov;52(5):1194-5   [PMID:  20655688 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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