Document Detail

Atherosclerotic plaque characterization by spatial and temporal speckle pattern analysis.
MedLine Citation:
PMID:  18007856     Owner:  NLM     Status:  In-Data-Review    
Improved methods are needed to identify the vulnerable coronary plaques responsible for acute myocardial infraction or sudden cardiac death. We describe a method for characterizing the structure and biomechanical properties of atherosclerotic plaques based on speckle pattern fluctuations. Near-field speckle images were acquired from five human aortic specimens ex vivo. The speckle decorrelation time constant varied significantly for vulnerable aortic plaques (tau=40 ms) versus stable plaques (tau=400 ms) and normal aorta (tau=500 ms) . These initial results indicate that different atherosclerotic plaque types may be distinguished by analysis of temporal and spatial speckle pattern fluctuations.
Guillermo J Tearney; Brett E Bouma
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Optics letters     Volume:  27     ISSN:  0146-9592     ISO Abbreviation:  Opt Lett     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2007-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708433     Medline TA:  Opt Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  533-5     Citation Subset:  -    
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