Document Detail

Atherosclerotic expansive remodeled plaques: a wolf in sheep's clothing.
MedLine Citation:
PMID:  12566977     Owner:  NLM     Status:  MEDLINE    
Geometric arterial remodeling is an important determinant of luminal narrowing in atherosclerotic disease. Expansive remodeling retards while constrictive remodeling accelerates luminal narrowing by plaque formation. Cross-sectional as well as follow-up studies revealed that expansive remodeling is associated with adverse cardiovascular events and a vulnerable plaque phenotype. Although the relation between expansive remodeling and plaque vulnerability is associative rather than causal, expansively remodeled plaques should be considered as a wolf in sheep's clothes. Further understanding of the processes that regulate arterial remodeling and plaque rupture may lead to new strategies to responsibly manipulate these processes for the benefit of patient outcomes.
Gerard Pasterkamp; Peter F Fitzgerald; Dominique P V de Kleijn
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of vascular research     Volume:  39     ISSN:  1018-1172     ISO Abbreviation:  J. Vasc. Res.     Publication Date:    2002 Nov-Dec
Date Detail:
Created Date:  2003-02-04     Completed Date:  2003-03-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9206092     Medline TA:  J Vasc Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  514-23     Citation Subset:  IM    
Copyright Information:
Copyright 2002 S. Karger AG, Basel
Laboratory of Experimental Cardiology, University Medical Center, Heidelberglaan 100, Room G02.523, NL-3584 CX Utrecht, The Netherlands.
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MeSH Terms
Coronary Artery Disease / pathology*,  physiopathology*
Coronary Circulation*
Ventricular Remodeling / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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