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Atherosclerotic arterial wall change of non-stenotic intracracranial arteries on high-resolution MRI at 3.0T: Correlation with cerebrovascular risk factors and white matter hyperintensity.
MedLine Citation:
PMID:  25190670     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Prior to detecting intracranial arterial stenosis, atherosclerotic wall change or plaque with positive remodeling can be evaluated with high-resolution MRI (HRMRI). We prospectively evaluate atherosclerotic arterial wall change in patients without intracranial stenosis using HRMRI at 3.0T and correlate the atherosclerotic change, cerebrovascular risk factors, and white matter hyperintensity (WMH).
METHODS: Patients were prospectively recruited for one year and underwent brain MRI, TOF-MRA and HRMRI using axial 3D T1 FSE of the intracranial arteries. After excluding patients with intracranial stenosis, two neuroradiologists graded the atherosclerotic change of the intracranial arterial wall on HRMRI and WMH using a 4-point scale. The relationship between atherosclerotic changes on HRMRI, cerebrovascular risk factors, and WMH were statistically evaluated.
RESULTS: Eighty-three patients without intracranial arterial stenosis were finally included. Older age (p=0.000), hypertension (p=0.002), and hyperlipidemia (p=0.007) were associated with severe atherosclerotic change on HRMRI. On multivariate analysis, older age (OR: 0.114; 95% CI: 0.033-0.397; p=0.001) and hypertension (OR: 0.178; 95% CI: 0.049-0.651; p=0.009) were significantly associated with severe atherosclerotic change on HRMRI. The presence of moderate and severe WMH was associated with older age, hypertension, and severe atherosclerotic change on HRMRI. On multivariate analysis, atherosclerotic change on HRMRI remained the only variable significantly associated with WMH (OR: 0.086; 95% CI: 0.016-0461; p=0.004).
CONCLUSION: Older age and hypertension are significantly associated with intracranial atherosclerotic change on HRMRI. Atherosclerotic change detected on HRMRI may be the strongest risk factor for WMH than any other cerebrovascular risk factor in patients without intracranial stenosis.
Authors:
Tae Hyung Kim; Jin Woo Choi; Hong Gee Roh; Won-Jin Moon; Sung Gyu Moon; Young Il Chun; Hahn Young Kim
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-15
Journal Detail:
Title:  Clinical neurology and neurosurgery     Volume:  126C     ISSN:  1872-6968     ISO Abbreviation:  Clin Neurol Neurosurg     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-9-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7502039     Medline TA:  Clin Neurol Neurosurg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-6     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier B.V. All rights reserved.
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