| Atherosclerotic Factors in PR3 Pulmonary Vasculitis. | |
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MedLine Citation:
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PMID: 22826078 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Autoimmune disease such as systemic lupus erythematosus or rheumatoid arthritis are connected with higher risk of atherosclerosis and cardiovascular complications and mortality. This results from inflammatory damage to the vessel wall by vasculitis. The aim of the present study was to evaluate whether patients with Wegener's granulomatosis (WG) and pulmonary involvement have an increased prevalence of atherosclerotic disease as characterized traditional risk factors. Twenty one patients with WG in remission and 15 control subject were entered to the study. Traditional risk factor for cardiovascular disease such as hyperglycemia, hypertension, smoking, obesity, and dyslipidemia were assessed. Both systolic and diastolic blood pressure were higher in WG patients (p<0.025). Total cholesterol, LDL and TG levels were markedly elevated in 18 of the 21 in pulmonary WG patients. Compared with controls, plasma levels of hsCRP were raised in WG patients; 3.68 (0.79-9.75) mg/l vs. 0.14 (0.12-0.59) mg/l (p<0.01). We conclude that non-pharmacological and pharmacological treatments of traditional risk factors are crucial to prevent cardiovascular disease in WG patients and thus should be part of therapy to control WG activity and damage caused by it. |
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Authors:
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K Zycinska; K Wardyn; T M Zielonka; A Nitsch-Osuch; R Smolarczyk; S Zarzycki; U Demkow; W Lukas; I Pirogowicz |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 755 ISSN: 0065-2598 ISO Abbreviation: - Publication Date: 2013 |
Date Detail:
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Created Date: 2012-7-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: - |
Other Details:
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Languages: ENG Pagination: 283-286 Citation Subset: - |
Affiliation:
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Department of Family Medicine, Internal and Metabolic Diseases Warsaw Medical University, Banacha 1a St., 02-097, Warsaw, Poland, kzycinska@poczta.fm. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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