Document Detail


Atherosclerotic Factors in PR3 Pulmonary Vasculitis.
MedLine Citation:
PMID:  22826078     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Autoimmune disease such as systemic lupus erythematosus or rheumatoid arthritis are connected with higher risk of atherosclerosis and cardiovascular complications and mortality. This results from inflammatory damage to the vessel wall by vasculitis. The aim of the present study was to evaluate whether patients with Wegener's granulomatosis (WG) and pulmonary involvement have an increased prevalence of atherosclerotic disease as characterized traditional risk factors. Twenty one patients with WG in remission and 15 control subject were entered to the study. Traditional risk factor for cardiovascular disease such as hyperglycemia, hypertension, smoking, obesity, and dyslipidemia were assessed. Both systolic and diastolic blood pressure were higher in WG patients (p<0.025). Total cholesterol, LDL and TG levels were markedly elevated in 18 of the 21 in pulmonary WG patients. Compared with controls, plasma levels of hsCRP were raised in WG patients; 3.68 (0.79-9.75) mg/l vs. 0.14 (0.12-0.59) mg/l (p<0.01). We conclude that non-pharmacological and pharmacological treatments of traditional risk factors are crucial to prevent cardiovascular disease in WG patients and thus should be part of therapy to control WG activity and damage caused by it.
Authors:
K Zycinska; K Wardyn; T M Zielonka; A Nitsch-Osuch; R Smolarczyk; S Zarzycki; U Demkow; W Lukas; I Pirogowicz
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  755     ISSN:  0065-2598     ISO Abbreviation:  -     Publication Date:  2013  
Date Detail:
Created Date:  2012-7-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  283-286     Citation Subset:  -    
Affiliation:
Department of Family Medicine, Internal and Metabolic Diseases Warsaw Medical University, Banacha 1a St., 02-097, Warsaw, Poland, kzycinska@poczta.fm.
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