| Atherosclerosis regression and high-density lipoproteins. | |
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MedLine Citation:
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PMID: 20828355 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atherosclerosis regression has been demonstrated clearly in animal experimental models and, to a lesser extent, in human clinical studies. Imaging techniques for study of the arterial wall are playing a key role in promoting our appreciation of regression. LDL lowering remains the mainstay of current lipid treatment, but given the multiple antiatherosclerotic functions of HDL, including reverse cholesterol transport, agents that target HDL may represent the next generation of treatment for atherosclerotic disease. Currently available agents, including nicotinic acid, have documented antiatherosclerotic effects and trials examining clinical outcomes in the context of contemporary LDL treatment are now underway. Future approaches to HDL treatment may include cholesteryl ester transfer protein inhibitors and apolipoprotein A-I mimetics. |
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Authors:
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Justin M S Lee; Robin P Choudhury |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert review of cardiovascular therapy Volume: 8 ISSN: 1744-8344 ISO Abbreviation: Expert Rev Cardiovasc Ther Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-10 Completed Date: 2010-12-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101182328 Medline TA: Expert Rev Cardiovasc Ther Country: England |
Other Details:
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Languages: eng Pagination: 1325-34 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Papworth Hospital, Cambridge, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atherosclerosis / blood, drug therapy*, pathology Cholesterol Ester Transfer Proteins / antagonists & inhibitors Disease Progression Humans Hypolipidemic Agents / therapeutic use Lipoproteins, HDL / blood* Niacin / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol Ester Transfer Proteins; 0/Hypolipidemic Agents; 0/Lipoproteins, HDL; 59-67-6/Niacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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