| Atherosclerosis of middle cerebral artery: evaluation with high-resolution MR imaging at 3T. | |
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MedLine Citation:
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PMID: 19041971 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Three-dimensional time-of-flight magnetic resonance angiography (3D TOF MRA) has been wildly used in the diagnosis of intracranial artery diseases, but it only shows the arterial lumen and does not delineate the vessel wall. The aim of this study was to assess whether high resolution cross sectional magnetic resonance imaging (HRMRI) could compensate the limitation of 3D TOF MRA in the atherosclerotic disease of middle cerebral artery (MCA). METHODS: Fourty-eight suspected patients with atherosclerotic stenosis of MCA underwent 3D TOF MRA and HRMRI with a 3T scanner. The HRMRI was performed in 49 MCAs perpendicular to the M1 segment with T2-weighted imaging. Findings of HRMRI were compared with that of 3D MRA. RESULTS: HRMRI displayed the artery wall clearly, and showed 37 abnormalities, including 20 plaques and 17 wall thickening. The inter-observer reproducibility was moderate for wall abnormalities with k=0.75 (95% CI 0.59-0.91), and excellent for plaques with k=0.91 (95% CI 0.80-1.03). 3D TOF MRA showed 34 stenoses at the M1 segment. Five normal MCAs on 3D TOF MRA had abnormal wall (3 plaques and 2 wall-thickening) on HRMRI. Two stenoses on 3D TOF MRA showed normal wall structure on HRMRI, indicating a possible negative remodeling phenomenon. CONCLUSIONS: High-resolution MR imaging can clearly depict the wall structure of middle cerebral arteries. As a complementary method, HRMRI may compensate the limitation of 3D TOF MRA and help to detect atherosclerotic lesions not visualized by MRA. |
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Authors:
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Ming-li Li; Wei-hai Xu; Lan Song; Feng Feng; Hui You; Jun Ni; Shan Gao; Li-ying Cui; Zheng-yu Jin |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2008-10-25 |
Journal Detail:
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Title: Atherosclerosis Volume: 204 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-25 Completed Date: 2009-08-10 Revised Date: 2011-08-31 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 447-52 Citation Subset: IM |
Affiliation:
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Department of Radiology, Peking Union Medical College Hospital and Chinese Academy of Medical Science, Shuai Fu Yuan 1#, Dong Cheng District, Beijing 100730, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cerebral Angiography / methods* Constriction, Pathologic Female Humans Image Interpretation, Computer-Assisted Imaging, Three-Dimensional* Infarction, Middle Cerebral Artery / pathology* Intracranial Arteriosclerosis / pathology* Magnetic Resonance Angiography* Male Middle Aged Middle Cerebral Artery / pathology* Observer Variation Predictive Value of Tests Reproducibility of Results |
| Comments/Corrections | |
Erratum In:
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Atherosclerosis. 2011 Jul;217(1):296 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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