Document Detail

Atherosclerosis and its evolution in childhood.
MedLine Citation:
PMID:  3321985     Owner:  NLM     Status:  MEDLINE    
Cardiovascular risk factors in childhood are related to arterial wall changes that lead to atherosclerotic coronary artery disease in later life. Atherosclerosis begins early in life. The observations of early arterial wall connective tissue changes and accompanying early lipid deposition show the importance of understanding cardiovascular risk factors in children. Since risk factors found in childhood are potentially predictive of adult coronary heart disease, methods for prevention of atherosclerosis should begin in children. Rational strategies should be directed to removing atherogenic forces that work in a child at high risk. Primary prevention of atherosclerosis has its maximal potential when begun before advanced irreversible lesions can occur. Consideration needs to be directed to how cardiovascular connective tissue changes and lipid and calcium deposition can be modulated in the injury and healing processes. It is important to recognize that adult coronary artery disease is really a major pediatric problem.
G S Berenson; S R Srinivasan; D S Freedman; B Radhakrishnamurthy; E R Dalferes
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  294     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-01-28     Completed Date:  1988-01-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  429-40     Citation Subset:  AIM; IM    
Department of Medicine, Louisiana State University Medical Center, New Orleans 70112-2228.
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MeSH Terms
Arteries / physiopathology
Arteriosclerosis / etiology*,  pathology,  physiopathology
Connective Tissue / physiopathology
Risk Factors
Grant Support

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