Document Detail


Atherosclerosis influences the vasomotor response of epicardial coronary arteries to exercise.
MedLine Citation:
PMID:  2723067     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the vasomotion of epicardial coronary arteries during exercise and tested the hypotheses that abnormal vasoconstriction is related to the presence of atherosclerosis and may be related to endothelial dilator dysfunction. During cardiac catheterization quantitative coronary angiography was performed in 21 patients during supine bicycle exercise. 21 of 28 smooth, angiographically normal vessel segments dilated (14.0 +/- 1.8%) during exercise; four smooth segments did not change whereas only three constricted. In contrast, 15 of 16 vessel segments with irregularities constricted in response to exercise (17.0 +/- 0.1%) with only one segment dilating. All 10 stenotic segments constricted to exercise (23 +/- 4%). Six patients also received intracoronary acetylcholine before exercise to test endothelium-dependent dilator function. In five of six patients all nine vessel segments showed the same directional response to acetylcholine and exercise. Three irregular and two stenotic segments constricted with acetylcholine (51 +/- 21%) and exercise (9.0 +/- 0.6%). In contrast, four smooth segments dilated to acetylcholine (19 +/- 6%) and exercise (9 +/- 1%). Both exercise and acetylcholine generally dilated smooth but constricted irregular and stenosed coronary segments. It appears likely that atherosclerosis plays an important role in the abnormal vasomotion of diseased coronary arteries during exercise and the pattern of abnormality suggests impairment of vasodilator function.
Authors:
J B Gordon; P Ganz; E G Nabel; R D Fish; J Zebede; G H Mudge; R W Alexander; A P Selwyn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  83     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-07-12     Completed Date:  1989-07-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1946-52     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Adult
Catecholamines / biosynthesis
Coronary Angiography
Coronary Artery Disease / blood,  physiopathology*,  radiography
Coronary Vessels / drug effects,  physiopathology*
Exercise*
Female
Hemodynamics
Humans
Male
Middle Aged
Muscle, Smooth / physiopathology,  radiography
Pericardium / drug effects,  physiopathology*
Vasomotor System / drug effects,  physiopathology*
Grant Support
ID/Acronym/Agency:
HL-01045/HL/NHLBI NIH HHS; HL-01957/HL/NHLBI NIH HHS; HL-35295/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Catecholamines; 51-84-3/Acetylcholine
Comments/Corrections

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