Document Detail

Atherosclerosis: an inflammatory disease.
MedLine Citation:
PMID:  12696277     Owner:  NLM     Status:  MEDLINE    
Inflammation plays a pivotal role in both the development of atherosclerosis and the acute activation of the vascular wall with consequent local thrombosis and vasoconstriction (with or without plaque fissure). In many patients with unstable angina and acute myocardial infarction, systemic signs of inflammation are detectable. The use of systemic inflammatory markers, such as C-reactive protein as marker of disease activity and short- and long-term prognosis, seems to be of clinical value. Therefore, acute inflammatory reaction, detectable systematically, appears to be an independent determinant of prognosis in some patients with acute ischemic syndromes, but is not detectable in all. Understanding the causes of inflammation and the additional elusive components that result in the progression to aggressive acute coronary syndromes, is the future goal of cardiology.
G Liuzzo
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Rays     Volume:  26     ISSN:  0390-7740     ISO Abbreviation:  Rays     Publication Date:    2001 Oct-Dec
Date Detail:
Created Date:  2003-04-16     Completed Date:  2003-05-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7707724     Medline TA:  Rays     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  221-30     Citation Subset:  IM    
Istituto di Cardiologia, e Fondazione per il Cuore, Università Cattolica del S. Cuore, Policlinico A. Gemelli, 8, 00168 Roma, Italy.
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MeSH Terms
Angina, Unstable / blood
Arteriosclerosis / blood*,  pathology
C-Reactive Protein / analysis
Cell Adhesion Molecules / blood
Cytokines / blood
Inflammation / blood*,  pathology
Myocardial Infarction / blood
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/Cytokines; 9007-41-4/C-Reactive Protein

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