| Atherosclerosis in survivors of Kawasaki disease. | |
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MedLine Citation:
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PMID: 19595365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To test the hypothesis that long-term survivors of low-risk Kawasaki disease (KD) have ongoing vascular inflammation and dysfunction and a higher risk of accelerated atherosclerosis than healthy control subjects. STUDY DESIGN: Twenty-eight patients with KD (7-20 years after acute illness) and 27 age-matched healthy control subjects were examined for medical and dietary history, serum markers of atherosclerotic risk and inflammation, carotid intimal-medial thickness (CIMT) with vascular ultrasound scanning and arterial stiffness with applanation tonometry. RESULTS: Patients and control subjects were similar in age, sex, body mass index, waist-to-hip ratio, blood pressure, cigarette smoking, family history, diet, high-density lipoprotein cholesterol level, lipoprotein (a) level, homocysteine level, glucose level, insulin level, CIMT, arterial stiffness, C-reactive protein level, and inflammatory cytokine level. Levels of total cholesterol and apolipoprotein B were significantly higher in patients with KD than in control subjects. CONCLUSIONS: There was no evidence of increased atherosclerosis. Small but significant differences in cholesterol and apolipoprotein B levels could suggest increased future risk for atherosclerosis and warrant further study. |
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Authors:
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Monesha Gupta-Malhotra; Dorota Gruber; Seena S Abraham; Mary J Roman; John B Zabriskie; Lisa C Hudgins; Patrick A Flynn; Daniel M Levine; Uzoma Okorie; Aline Baday; Myles S Schiller; Janet Maturi; Diane Meehan; Joshua Dyme; Thomas S Parker; Knut M Wittkowski; Welton M Gersony; Rubin S Cooper |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pediatrics Volume: 155 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-23 Completed Date: 2009-10-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 572-7 Citation Subset: AIM; IM |
Affiliation:
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Division of Pediatric Cardiology, Department of Pediatrics, Komansky Center for Children's Health, New York-Presbyterian Hospital, Weill-Cornell Medical College, New York, NY, USA. monesha.gupta@uth.tmc.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute-Phase Proteins
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metabolism Adolescent Adult Atherosclerosis / diagnosis, epidemiology* Biological Markers / metabolism Carotid Arteries / pathology Case-Control Studies Cytokines / blood Female Humans Inflammation Mediators / blood Lipids / blood Male Mucocutaneous Lymph Node Syndrome / complications, metabolism*, pathology* Risk Factors Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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M01-RR00102/RR/NCRR NIH HHS; UL1 RR024143/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Acute-Phase Proteins; 0/Biological Markers; 0/Cytokines; 0/Inflammation Mediators; 0/Lipids |
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