Document Detail


Atherosclerosis in rabbit vein grafts.
MedLine Citation:
PMID:  2719597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human coronary saphenous vein bypass grafts develop atherosclerosis more readily than do grafts made of internal mammary artery. The reasons for this increased susceptibility, particularly in the presence of hyperlipidemia, are not known. In this study in rabbits, we investigated the possibility that the increased susceptibility might be attributed to increased smooth muscle proliferation and foam cell accumulation in vein grafts compared to native artery. Hypercholesterolemic and control rabbits underwent placement of jugular vein grafts in the carotid artery. Dietary cholesterol content was adjusted to maintain serum cholesterol levels of 200 to 600 mg/dl in the fat-fed rabbits. The vein graft intimal thickness in hypercholesterolemic rabbits was greater than in normolipemic rabbits at 3 and 6 months after implant. The increased thickness in the hypercholesterolemic group was largely accounted for by an accumulation of lipid-laden macrophages. Medial thicknesses increased during the first month, remained constant at later times, and were similar in control and hypercholesterolemic animals. In both groups, endothelial and smooth muscle cell proliferation (thymidine labeling) increased immediately after graft implantation and declined at 3 and 6 months. No incremental mitogenic stimulus could be attributed to the hypercholesterolemia. In immunohistochemical preparations, the large foam cells were noted to be macrophages, and the intimal proliferating cells, to be smooth muscle.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
R M Zwolak; T R Kirkman; A W Clowes
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Arteriosclerosis (Dallas, Tex.)     Volume:  9     ISSN:  0276-5047     ISO Abbreviation:  Arteriosclerosis     Publication Date:    1989 May-Jun
Date Detail:
Created Date:  1989-06-20     Completed Date:  1989-06-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8401388     Medline TA:  Arteriosclerosis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  374-9     Citation Subset:  IM    
Affiliation:
University of Washington School of Medicine, Department of Surgery, Seattle 98195.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteriosclerosis / metabolism,  pathology*
Carotid Arteries / surgery
Cell Division
Diet, Atherogenic
Endothelium, Vascular / ultrastructure
Lipid Metabolism
Macrophages / metabolism,  ultrastructure
Male
Muscle, Smooth, Vascular / pathology,  ultrastructure
Rabbits
Saphenous Vein / pathology,  transplantation*,  ultrastructure
Grant Support
ID/Acronym/Agency:
HL 18645/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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