| Atherosclerosis in rabbit vein grafts. | |
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MedLine Citation:
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PMID: 2719597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human coronary saphenous vein bypass grafts develop atherosclerosis more readily than do grafts made of internal mammary artery. The reasons for this increased susceptibility, particularly in the presence of hyperlipidemia, are not known. In this study in rabbits, we investigated the possibility that the increased susceptibility might be attributed to increased smooth muscle proliferation and foam cell accumulation in vein grafts compared to native artery. Hypercholesterolemic and control rabbits underwent placement of jugular vein grafts in the carotid artery. Dietary cholesterol content was adjusted to maintain serum cholesterol levels of 200 to 600 mg/dl in the fat-fed rabbits. The vein graft intimal thickness in hypercholesterolemic rabbits was greater than in normolipemic rabbits at 3 and 6 months after implant. The increased thickness in the hypercholesterolemic group was largely accounted for by an accumulation of lipid-laden macrophages. Medial thicknesses increased during the first month, remained constant at later times, and were similar in control and hypercholesterolemic animals. In both groups, endothelial and smooth muscle cell proliferation (thymidine labeling) increased immediately after graft implantation and declined at 3 and 6 months. No incremental mitogenic stimulus could be attributed to the hypercholesterolemia. In immunohistochemical preparations, the large foam cells were noted to be macrophages, and the intimal proliferating cells, to be smooth muscle.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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R M Zwolak; T R Kirkman; A W Clowes |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Arteriosclerosis (Dallas, Tex.) Volume: 9 ISSN: 0276-5047 ISO Abbreviation: Arteriosclerosis Publication Date: 1989 May-Jun |
Date Detail:
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Created Date: 1989-06-20 Completed Date: 1989-06-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8401388 Medline TA: Arteriosclerosis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 374-9 Citation Subset: IM |
Affiliation:
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University of Washington School of Medicine, Department of Surgery, Seattle 98195. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteriosclerosis / metabolism, pathology* Carotid Arteries / surgery Cell Division Diet, Atherogenic Endothelium, Vascular / ultrastructure Lipid Metabolism Macrophages / metabolism, ultrastructure Male Muscle, Smooth, Vascular / pathology, ultrastructure Rabbits Saphenous Vein / pathology, transplantation*, ultrastructure |
| Grant Support | |
ID/Acronym/Agency:
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HL 18645/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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