Document Detail

Atherosclerosis in the human common carotid artery. A morphometric study of 31 specimens.
MedLine Citation:
PMID:  11795827     Owner:  NLM     Status:  MEDLINE    
The carotid artery bifurcation is of special interest to both the pathologist because of its frequent atherosclerotic depositions, and to the fluidmechanicist because of its complex flow properties. However, current knowledge is incomplete regarding the level and position of atherosclerotic plaques in the carotid bifurcation and their quantitative correlation with its geometry. The study presented here is intended to fill that knowledge gap and try to quantify the geometrical risk factors. During the post-mortem the arteries were excised and filled with a resin at the proper transmural pressure of 80 mm Hg. Thirty-one vessel casts of the carotid artery from twenty-three autopsied individuals were made. The vessel casts were used to measure several geometrical parameters. After fabrication of the vessel casts each artery was investigated according to pathomorphological procedure. An atherometric system (AS) indicating the level of atherosclerotic lesions was applied. The specimens were divided into three groups according to the level of atherosclerosis. The comparison was made between the level of wall alteration of the main branches of the carotid bifurcation (common, internal and external carotid branch), and between these three groups themselves. Further, we conducted a comparison of the averaged geometric parameters in different groups to define the correlations between atherosclerotic lesions and geometric parameters. The results show that the most advanced lesions (fibrous and severe plaques) with about 70% of all lesions were mainly found in the internal and the external carotid branches, compared with only 25% for the common carotid branch. The comparative analysis showed that a relatively high carotid sinus enlargement of > 1.2 of the common carotid branch diameter is a most significant geometric risk factor among those investigated, whereas there was no correlation between branch angles and atherosclerosis. In conclusion, the quantification of atherosclerotic risk factors is very important in the investigation of atherosclerotic disease development.
L Goubergrits; K Affeld; J Fernandez-Britto; L Falcon
Related Documents :
2646457 - External carotid-external carotid crossover anastomosis for reconstruction of common ca...
17052907 - Non-bifurcating cervical carotid artery.
17356797 - Inactivity of nitric oxide synthase gene in the atherosclerotic human carotid artery.
7153167 - An ultrastructural investigation of a baroreceptor zone in the common carotid artery of...
23008157 - Aortocoronary saphenous vein graft rupture during diagnostic angiography.
23743077 - 3-dimensional echocardiography and its role in preoperative mitral valve evaluation.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology, research and practice     Volume:  197     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2001  
Date Detail:
Created Date:  2002-01-17     Completed Date:  2002-06-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  803-9     Citation Subset:  IM    
Biofluidmechanics Laboratory, Universitätsklinikum Charité, Humboldt University of Berlin, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Arteriosclerosis / classification,  pathology*
Carotid Artery Diseases / pathology*
Carotid Artery, Common / pathology*
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Immunohistochemical expression of the intracellular component of galectin-8 in squamous cell metapla...
Next Document:  Expression of the proto-oncogene c-myc in human stenotic aortocoronary bypass grafts.