| Atherosclerosis in Octodon degus (degu) as a model for human disease. | |
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MedLine Citation:
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PMID: 20630529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Animal models of atherosclerosis are essential to elucidate disease mechanisms and develop new therapies. Each model features advantages and disadvantages in exemplifying the pathophysiology of human atherosclerosis. Diet-induced development of atherosclerosis in Octodon degus (degu) was examined to demonstrate the potential of the degu as a model of human atherosclerosis. METHODS: Degus were fed for 16 weeks with either normal chow or chow containing 0.25% cholesterol and 6% palm oil to induce atherosclerosis. The lipid compositions of plasma lipoproteins and aortas were determined. Locations of aortic lesions were mapped by imaging of fluorescently stained aortic lesions. Lesion morphology in the brachiocephalic artery was detected by histological staining. RESULTS: Total plasma cholesterol in chow-fed degus was distributed approximately 60% in HDL, 30% in LDL and less than 10% in VLDL. Cholesterol-fed degus exhibited 4- to 5-fold increases in total plasma cholesterol, principally in the VLDL and LDL fractions. Cholesteryl ester transfer protein activity of similar magnitude to that in human plasma was detected in chow-fed degu plasma. Cholesterol-fed degus developed cholesteryl ester-rich atherosclerotic lesions throughout the aorta. Histological examination of lesions in the brachiocephalic artery showed well-formed, foam cell-rich lesions populated with inflammatory cells. It is also noteworthy that all the degus in this study exhibited hyperglycemia. CONCLUSION: These results demonstrate that degus have a human-like lipoprotein metabolism and develop extensive atherosclerosis with cholesterol feeding in the presence of hyperglycemia. These features, combined with the manageable size and handling characteristics, point to the potential of the degu as a useful model for atherosclerosis research. |
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Authors:
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Reynold Homan; Jeffrey C Hanselman; Sandra Bak-Mueller; Michelle Washburn; Patrick Lester; Heather E Jensen; Stephen L Pinkosky; Christine Castle; Bruce Taylor |
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Publication Detail:
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Type: Journal Article Date: 2010-06-11 |
Journal Detail:
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Title: Atherosclerosis Volume: 212 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-03 Completed Date: 2010-12-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 48-54 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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AlphaCore Pharma, 333 Parkland Plaza, Suite 5, Ann Arbor, MI, USA. reyn.homan@alphacorepharma.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / metabolism, pathology Aortic Diseases* / blood, etiology, pathology Atherosclerosis* / blood, etiology, pathology Biological Markers / blood Blood Glucose / metabolism Brachiocephalic Trunk / metabolism, pathology Cholesterol Ester Transfer Proteins / blood Cholesterol, Dietary / blood Cholesterol, HDL / blood Cholesterol, LDL / blood Cholesterol, VLDL / blood Disease Models, Animal* Female Humans Hyperglycemia / blood, etiology Male Octodon* Plant Oils Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Blood Glucose; 0/Cholesterol Ester Transfer Proteins; 0/Cholesterol, Dietary; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Cholesterol, VLDL; 0/Plant Oils; 8002-75-3/palm oil |
| Comments/Corrections | |
Comment In:
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Atherosclerosis. 2010 Sep;212(1):32-3
[PMID:
20638066
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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