| Atherosclerosis of cynomolgus monkeys hyper- and hyporesponsive to dietary cholesterol. Lack of effect of vasectomy. | |
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MedLine Citation:
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PMID: 3190556 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A moderately atherogenic diet was fed to young adult cynomolgus macaque males that were observed to be either hypo- or hyperresponsive to dietary cholesterol and who were randomized into groups to be either vasectomized or sham-vasectomized. The extent of atherosclerosis was found to be considerably greater at all arterial sites studied for the monkeys that were hyperresponsive to dietary cholesterol. The differences in atherosclerosis development among the hyperresponder monkeys occurred primarily in the proximal portions of the coronary arteries, the proximal and distal portions of the common carotid arteries, and only in the most proximal portions of the femoral arteries. There were no significant effects of vasectomy or sham vasectomy on atherosclerosis extent in either the hyper- or the hyporesponding groups, although there was a suggestion of somewhat larger lesions in the left circumflex coronary artery of hyperresponder monkeys that were vasectomized and somewhat smaller atherosclerotic lesions in the left common carotid arteries of vasectomized monkeys. The data presented here do not support our first report of worsened atherosclerosis among cynomolgus monkeys fed diets high in cholesterol. The findings of the current study are consistent with recent epidemiological studies of vasectomized and nonvasectomized human males. |
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Authors:
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T B Clarkson; N J Alexander; T M Morgan |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Arteriosclerosis (Dallas, Tex.) Volume: 8 ISSN: 0276-5047 ISO Abbreviation: Arteriosclerosis Publication Date: 1988 Sep-Oct |
Date Detail:
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Created Date: 1988-12-20 Completed Date: 1988-12-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8401388 Medline TA: Arteriosclerosis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 488-98 Citation Subset: IM |
Affiliation:
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Arteriosclerosis Research Center, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 21703. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies / analysis Aorta, Abdominal / pathology Aorta, Thoracic / pathology Arteriosclerosis / etiology*, pathology Carotid Arteries / pathology Cell Adhesion Cholesterol / blood Cholesterol, Dietary / adverse effects* Cholesterol, HDL / blood Coronary Vessels / pathology Diet, Atherogenic Endothelium, Vascular / pathology Femoral Artery / pathology Lipids / blood Macaca fascicularis Male Monocytes / pathology Spermatozoa / immunology Vasectomy / adverse effects* |
| Grant Support | |
ID/Acronym/Agency:
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HL 14164/HL/NHLBI NIH HHS; N01 HD 8 2827/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Cholesterol, Dietary; 0/Cholesterol, HDL; 0/Lipids; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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