Document Detail

Atherosclerosis of cynomolgus monkeys hyper- and hyporesponsive to dietary cholesterol. Lack of effect of vasectomy.
MedLine Citation:
PMID:  3190556     Owner:  NLM     Status:  MEDLINE    
A moderately atherogenic diet was fed to young adult cynomolgus macaque males that were observed to be either hypo- or hyperresponsive to dietary cholesterol and who were randomized into groups to be either vasectomized or sham-vasectomized. The extent of atherosclerosis was found to be considerably greater at all arterial sites studied for the monkeys that were hyperresponsive to dietary cholesterol. The differences in atherosclerosis development among the hyperresponder monkeys occurred primarily in the proximal portions of the coronary arteries, the proximal and distal portions of the common carotid arteries, and only in the most proximal portions of the femoral arteries. There were no significant effects of vasectomy or sham vasectomy on atherosclerosis extent in either the hyper- or the hyporesponding groups, although there was a suggestion of somewhat larger lesions in the left circumflex coronary artery of hyperresponder monkeys that were vasectomized and somewhat smaller atherosclerotic lesions in the left common carotid arteries of vasectomized monkeys. The data presented here do not support our first report of worsened atherosclerosis among cynomolgus monkeys fed diets high in cholesterol. The findings of the current study are consistent with recent epidemiological studies of vasectomized and nonvasectomized human males.
T B Clarkson; N J Alexander; T M Morgan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Arteriosclerosis (Dallas, Tex.)     Volume:  8     ISSN:  0276-5047     ISO Abbreviation:  Arteriosclerosis     Publication Date:    1988 Sep-Oct
Date Detail:
Created Date:  1988-12-20     Completed Date:  1988-12-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8401388     Medline TA:  Arteriosclerosis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  488-98     Citation Subset:  IM    
Arteriosclerosis Research Center, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 21703.
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MeSH Terms
Antibodies / analysis
Aorta, Abdominal / pathology
Aorta, Thoracic / pathology
Arteriosclerosis / etiology*,  pathology
Carotid Arteries / pathology
Cell Adhesion
Cholesterol / blood
Cholesterol, Dietary / adverse effects*
Cholesterol, HDL / blood
Coronary Vessels / pathology
Diet, Atherogenic
Endothelium, Vascular / pathology
Femoral Artery / pathology
Lipids / blood
Macaca fascicularis
Monocytes / pathology
Spermatozoa / immunology
Vasectomy / adverse effects*
Grant Support
Reg. No./Substance:
0/Antibodies; 0/Cholesterol, Dietary; 0/Cholesterol, HDL; 0/Lipids; 57-88-5/Cholesterol

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