| Atherosclerosis aggravates ischemia/reperfusion injury in the gut and remote damage in the liver and the lung. | |
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MedLine Citation:
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PMID: 21222016 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: We investigated whether mesenteric ischemia/reperfusion (I/R)-associated gut injury and remote liver and lung damage are affected by prevalent atherosclerosis. METHODS: Mesenteric ischemia was induced in atherosclerotic ApoE-deficient (ApoE(-/-)) and control C57BL/6 mice by clamping the superior mesenteric artery for 30 min. Mesenteric microcirculatory dysfunction and leukocytic inflammation were studied in the terminal ileum by intravital fluorescence microscopy (IVM). Histological analyses included quantitative assessment of parenchymal injury in the terminal ileum, liver and lung. RESULTS: In the gut, IVM of the terminal ileum revealed aggravated postischemic microcirculatory dysfunction and absence of reactive hyperemia-induced vasodilation in atherosclerotic mice compared to controls. In addition, leukocyte-endothelial cell adhesive interactions, i.e. rolling and firm adhesion, were significantly increased in atherosclerotic animals. This was associated with enhanced mucosal tissue damage in ApoE(-/-) mice. Moreover, mesenteric I/R-provoked remote parenchymal injury in the liver was found to be significantly aggravated in atherosclerotic mice. This was accompanied by enhanced neutrophilic lung inflammation in ApoE(-/-) mice. CONCLUSION: Prevalent generalized atherosclerosis not only aggravates splanchnic microcirculatory dysfunction and leukocytic inflammation in response to mesenteric I/R, but also exacerbates mucosal tissue damage and remote injury in the liver and the lung. |
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Authors:
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René Schramm; Frank Appel; Manfred Reinacher; Hans-Joachim Schäfers; Benjamin Bierbach; Jan Slotta; Henrik Thorlacius; Michael D Menger |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-9 |
Journal Detail:
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Title: Inflammation research : official journal of the European Histamine Research Society ... [et al.] Volume: - ISSN: 1420-908X ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508160 Medline TA: Inflamm Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Clinic of Cardiac Surgery, Ludwig-Maximilians-University of Munich-Grosshadern, Marchioninistr.15, 81377, Munich, Germany, reneschramm@live.de. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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