| Atherosclerosis and Dementia: A Cross-Sectional Study With Pathological Analysis of the Carotid Arteries. | |
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MedLine Citation:
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PMID: 21940957 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Previous ultrasound-based studies have shown an association between carotid artery atherosclerosis and dementia. Our aim was to investigate this association using postmortem examination. METHODS: Postmortem morphometric measurements of carotid stenosis and intima-media thickness were performed in individuals with dementia (n=112) and control subjects (n=577). Multivariate logistic regression models were applied. RESULTS: High-grade left internal carotid stenosis (≥70%) was associated with increased odds for dementia (OR, 2.30; 95% CI, 1.14-4.74; P=0.02). Intima-media thickness was not associated with dementia. CONCLUSIONS: The likelihood of dementia is increased with high-grade left internal carotid artery atherosclerosis after adjusting for demographic and cardiovascular risk factors. |
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Authors:
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Claudia K Suemoto; Ricardo Nitrini; Lea T Grinberg; Renata E L Ferretti; José M Farfel; Renata E P Leite; Paulo R Menezes; Felipe Fregni; Wilson Jacob-Filho; Carlos A Pasqualucci; |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-22 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: - ISSN: 1524-4628 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the Departments of Geriatrics, Neurology, Pathology, and Preventive Medicine, University of Sao Paulo Medical School, Sao Paulo, Brazil; the Memory and Aging Center, University of California San Francisco, San Francisco, CA; and the Departments of Physical Medicine & Rehabilitation and Neurology, Harvard Medical School, Boston, MA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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