Document Detail

Atherosclerosis and Dementia: A Cross-Sectional Study With Pathological Analysis of the Carotid Arteries.
MedLine Citation:
PMID:  21940957     Owner:  NLM     Status:  Publisher    
BACKGROUND AND PURPOSE: Previous ultrasound-based studies have shown an association between carotid artery atherosclerosis and dementia. Our aim was to investigate this association using postmortem examination. METHODS: Postmortem morphometric measurements of carotid stenosis and intima-media thickness were performed in individuals with dementia (n=112) and control subjects (n=577). Multivariate logistic regression models were applied. RESULTS: High-grade left internal carotid stenosis (≥70%) was associated with increased odds for dementia (OR, 2.30; 95% CI, 1.14-4.74; P=0.02). Intima-media thickness was not associated with dementia. CONCLUSIONS: The likelihood of dementia is increased with high-grade left internal carotid artery atherosclerosis after adjusting for demographic and cardiovascular risk factors.
Claudia K Suemoto; Ricardo Nitrini; Lea T Grinberg; Renata E L Ferretti; José M Farfel; Renata E P Leite; Paulo R Menezes; Felipe Fregni; Wilson Jacob-Filho; Carlos A Pasqualucci;
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-22
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  -     ISSN:  1524-4628     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the Departments of Geriatrics, Neurology, Pathology, and Preventive Medicine, University of Sao Paulo Medical School, Sao Paulo, Brazil; the Memory and Aging Center, University of California San Francisco, San Francisco, CA; and the Departments of Physical Medicine & Rehabilitation and Neurology, Harvard Medical School, Boston, MA.
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