| Atheroprotective effects of bilberry extracts in apo E-deficient mice. | |
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MedLine Citation:
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PMID: 19891504 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Previous studies have demonstrated that the intake of berry foods was associated with a reduced risk of cardiovascular diseases. The aim of the present study was to evaluate the effects of two bilberry extracts, one rich in anthocyanins extracted from untreated bilberries (BE) and a second one extracted from yeast-fermented bilberries (FBE), on the development of atherosclerosis in apolipoprotein E-deficient mice (apo E(-/-)). Apo E(-/-) mice received for 16 weeks a diet supplemented with 0.02% of either BE or FBE. Atherosclerotic plaque area was measured in the aortic sinus. Supplementation of the diet with both bilberry extracts led to a significant inhibition of plaque development, whereas no effect on oxidative stress parameters or lipid profiles could be observed, suggesting the implication of other mechanisms of action. In addition, a better protection was observed with FBE, suggesting that the fermentation generates new bioactive compounds more effective in attenuating progression of the atherosclerotic lesions. |
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Authors:
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Aurelie Mauray; Dragan Milenkovic; Catherine Besson; Nelly Caccia; Christine Morand; Francoise Michel; Andrzej Mazur; Augustin Scalbert; Catherine Felgines |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 57 ISSN: 1520-5118 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
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Languages: eng Pagination: 11106-11 Citation Subset: IM |
Affiliation:
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INRA, Unité de Nutrition Humaine, UMR1019, Centre de Recherche de Clermont Ferrand/Theix, Saint Genès Champanelle, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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