| Atherogenic lipid profile of Brazilian near-term newborns. | |
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MedLine Citation:
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PMID: 15917957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiovascular disease is the primary cause of death in Brazil. Recent studies have shown that low birth weight and preterm birth are linked to a higher prevalence of cardiovascular disease. The aim of the present study was to compare the levels of lipids and apolipoproteins and atherogenic indexes between term and near-term newborn infants. A sample of umbilical cord blood was obtained from 135 newborns (66 males) divided into two groups: 25 near-term neonates (35-36.6 weeks of gestational age) and 110 term neonates (37-42 weeks of gestational age). The total cholesterol concentrations were higher in the near-term neonates than in the term group (94.04 +/- 8.02 vs 70.42 +/- 1.63 mg/dl, P < 0.01), due to an increase in the LDL-cholesterol fraction in the near-term group (57.76 +/- 6.39 vs 34.38 +/- 1.29 mg/dl, P < 0.001). The atherogenic indexes (total cholesterol/HDL-cholesterol, LDL-cholesterol/HDL-cholesterol and apolipoprotein B/apolipoprotein A-I) were higher in the near-term group (P < 0.001, P < 0.001, and P < 0.05, respectively). The gestational age of the newborns was inversely correlated with total cholesterol and LDL-cholesterol, and also with the total cholesterol/HDL-cholesterol and LDL-cholesterol/HDL-cholesterol indexes. These findings demonstrate that the lipid profile is worse in the group of near-term neonates compared with the term group. Future studies are needed to determine if this atherogenic profile in near-term neonates can affect body metabolism, increasing the risk for cardiovascular diseases in adult life. |
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Authors:
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I M C G Pardo; B Geloneze; M A Tambascia; A A Barros-Filho |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-05-25 |
Journal Detail:
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Title: Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] Volume: 38 ISSN: 0100-879X ISO Abbreviation: Braz. J. Med. Biol. Res. Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-05-26 Completed Date: 2005-12-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8112917 Medline TA: Braz J Med Biol Res Country: Brazil |
Other Details:
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Languages: eng Pagination: 755-60 Citation Subset: IM |
Affiliation:
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Departamento de Pediatria, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Brasil. doctorpardo@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apolipoproteins
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blood* Biological Markers / blood Brazil Cardiovascular Diseases / blood* Cholesterol / blood* Cholesterol, HDL / blood Cholesterol, LDL / blood Female Fetal Blood / chemistry* Gestational Age Humans Infant, Low Birth Weight / blood Infant, Newborn Male Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins; 0/Biological Markers; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 57-88-5/Cholesterol |
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