Document Detail

Atherogenesis in experimental uremia.
MedLine Citation:
PMID:  7332607     Owner:  NLM     Status:  MEDLINE    
The development of experimental atherosclerosis was studied in subtotally nephrectomized rats which were subjected to preimmunization with horseradish peroxidase and subsequent feeding with atherogenic diet. Both in sham-operated pair-fed control animals and in uremic animals, the atherogenic diet caused hyperlipemia which was more pronounced in uremic than in control animals (control animals: triglycerides 1.11 +/- 0.04 mmol/l; cholesterol 5.82 +/- 0.21 mmol/l; uremia: triglycerides 1.33 +/- 0.06; cholesterol 10.9 +/- 0.31). An increase of cholesterol was seen both in the VLDL and in the LDL fractions. Despite more pronounced hyperlipemia, lipid concentration in the aortic wall was not increased nor were more marked histological abnormalities encountered in the aorta of uremic animals (cholesterol-fed control: cholesterol 95.4 +/- 4.4 micrograms/mg protein; phospholipids 2.42 +/- 0.9 micrograms/ml protein; cholesterol-fed uremia: cholesterol 96.8 +/- 4.9; phospholipids 2.52 +/- 0.8). The results suggest that despite hyperlipemia short-term experimental renal insufficiency does not promote atherogenesis.
A Horsch; E Ritz; C C Heuck; W Hofmann; E Kühne; M Bisson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Atherosclerosis     Volume:  40     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:    1981 Nov-Dec
Date Detail:
Created Date:  1982-04-20     Completed Date:  1982-04-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  279-89     Citation Subset:  IM    
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MeSH Terms
Aorta / metabolism
Arteriosclerosis / etiology*,  pathology
Cholesterol / blood
Lipoproteins / blood
Rats, Inbred Strains
Uremia / blood,  complications*
Vitamin D / metabolism
Reg. No./Substance:
0/Lipoproteins; 1406-16-2/Vitamin D; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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