| Atherogenesis Insights from the study of transgenic and gene-targeted mice. | |
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MedLine Citation:
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PMID: 21244939 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Owing to the investigative power of classical mouse genetics and the development of transgenic and gene-targeting technologies, the mouse has increasingly been used to study atherogenesis. Investigators have manipulated the plasma levels of several proteins involved in lipid metabolism through the engineering of mice and assessed the impact of these changes on the progression of murine atherogenesis. These studies have established causal relationships between the expression of defined genetic elements and atherosclerosis in a manner not feasible in humans. Studies of transgenic mice with genetically altered levels of apolipoproteins A-I, (a), and E have provided important insights into the in vivo role of these proteins in atherogenesis. These studies illustrate the potential to dissect the complex genetics of atherosclerosis susceptibility with the use of transgenic and gene-targeted mice. |
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Authors:
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L Stoltzfus; E M Rubin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Trends in cardiovascular medicine Volume: 3 ISSN: 1050-1738 ISO Abbreviation: Trends Cardiovasc. Med. Publication Date: 1993 Jul-Aug |
Date Detail:
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Created Date: 2011-01-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9108337 Medline TA: Trends Cardiovasc Med Country: United States |
Other Details:
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Languages: eng Pagination: 130-4 Citation Subset: - |
Copyright Information:
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Copyright © 1993. Published by Elsevier Inc. |
Affiliation:
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Life Sciences Division, Lawrence Berkeley Laboratory, University of California, Berkeley, CA 94720, USA. |
Export Citation:
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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