Document Detail


Atheroembolic renal disease: clinical findings of 11 cases.
MedLine Citation:
PMID:  12560589     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Atheromatous embolism is a systemic disease resulting from cholesterol crystal embolization in many organs, including the kidneys. To characterize atheroembolic renal disease (AERD), we retrospectively evaluated 11 patients with acute renal failure after vascular surgery, vascular radiology investigations, and anticoagulation at Miyazaki Medical College from 1994 to 2001. The diagnosis of cholesterol atheromatous embolism was confirmed by tissue examination or clinical grounds. The patients were all elderly men (average age of 66.8 years) with a history of hypertension (55%), diabetes mellitus (45%), hyperlipidemia (45%), and coronary artery disease (18%). Seven patients had livedo reticularis, and 4 had blood eosinophilia. Clinically, 7 patients were managed conservatively and 5 of them improved, whereas 4 patients required dialysis and developed chronic renal failure or died. The serum creatinine levels of the improved patients were significantly lower (1.28+/-0.3 mg/dl, p < 0.005) than the non-improved ones (7.70+/-3.6). The number of eosinophils was significantly higher in the improved patients (576+/-295 /ml, p < 0.05) than in the non-improved ones (208+/-206). However, no significant difference was observed in the levels of serum cholesterol and C-reactive protein among these patients. Since the population at risk for AERD is growing, we should recognize this disease as a cause of acute renal failure.
Authors:
Seiichiro Hara; Yujiro Asada; Shouichi Fujimoto; Kousuke Marutsuka; Kinta Hatakeyama; Akinobu Sumiyoshi; Tanenao Eto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of atherosclerosis and thrombosis     Volume:  9     ISSN:  1340-3478     ISO Abbreviation:  J. Atheroscler. Thromb.     Publication Date:  2002  
Date Detail:
Created Date:  2003-01-31     Completed Date:  2003-10-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9506298     Medline TA:  J Atheroscler Thromb     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  288-91     Citation Subset:  IM    
Affiliation:
First Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Miyazaki, Japan. shara@post1.miyazaki-med.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Aorta / pathology
Embolism, Cholesterol / complications*,  pathology*,  therapy
Eosinophilia / complications,  pathology,  therapy
Humans
Kidney Failure, Acute / etiology*,  pathology*,  therapy
Male
Middle Aged
Prognosis
Treatment Outcome

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