Document Detail

Atenolol 4% eye drops and glaucoma. A double-blind short-term clinical trial of a new beta1-adrenergic blocking agent.
MedLine Citation:
PMID:  341739     Owner:  NLM     Status:  MEDLINE    
We studied the effect of a single dose of atenolol 4% eye drops on 21 patients with primary open-angle glaucoma during a double-blind clinical trial. We monitored intraocular pressure (IOP), blood pressure, and pulse rate. At three and six h after medication, the average reduction of IOP was 7.3 and 4.1 mm Hg, respectively, compared to the baseline readings without medication. The reduction of IOP at four h after medication was 6.3 mm Hg compared to the pretreatment value. This corresponds to an average change from the pretreatment value of 22%. Blood pressure and pulse rate did not change significantly. We observed no subjective or objective ocular side effects. The duration of the effect of a single dose of atenolol 4% eye drops is approximately six h. Atenolol 4% eye drops may become a useful agent in the medical treatment of glaucoma if a long-term effect and no ocular side effects (especially a local anesthetic effect) can be proven.
F E Ros; C L Dake; L Offerhaus; E L Greve
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology     Volume:  205     ISSN:  0065-6100     ISO Abbreviation:  Albrecht Von Graefes Arch Klin Exp Ophthalmol     Publication Date:  1977 Dec 
Date Detail:
Created Date:  1978-03-29     Completed Date:  1978-03-29     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0044637     Medline TA:  Albrecht Von Graefes Arch Klin Exp Ophthalmol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  61-70     Citation Subset:  IM    
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MeSH Terms
Atenolol / administration & dosage,  pharmacology,  therapeutic use*
Blood Pressure / drug effects
Clinical Trials as Topic
Drug Evaluation
Glaucoma / drug therapy*
Middle Aged
Ophthalmic Solutions / administration & dosage
Propanolamines / therapeutic use*
Pulse / drug effects
Time Factors
Reg. No./Substance:
0/Ophthalmic Solutions; 0/Placebos; 0/Propanolamines; 29122-68-7/Atenolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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