Document Detail

At the membrane frontier: a prospectus on the remarkable evolutionary conservation of polyprenols and polyprenyl-phosphates.
MedLine Citation:
PMID:  22093697     Owner:  NLM     Status:  MEDLINE    
Long-chain polyprenols and polyprenyl-phosphates are ubiquitous and essential components of cellular membranes throughout all domains of life. Polyprenyl-phosphates, which include undecaprenyl-phosphate in bacteria and the dolichyl-phosphates in archaea and eukaryotes, serve as specific membrane-bound carriers in glycan biosynthetic pathways responsible for the production of cellular structures such as N-linked protein glycans and bacterial peptidoglycan. Polyprenyl-phosphates are the only form of polyprenols with a biochemically-defined role; however, unmodified or esterified polyprenols often comprise significant percentages of the cellular polyprenol pool. The strong evolutionary conservation of unmodified polyprenols as membrane constituents and polyprenyl-phosphates as preferred glycan carriers in biosynthetic pathways is poorly understood. This review surveys the available research to explore why unmodified polyprenols have been conserved in evolution and why polyprenyl-phosphates are universally and specifically utilized for membrane-bound glycan assembly.
Meredith D Hartley; Barbara Imperiali
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-11-10
Journal Detail:
Title:  Archives of biochemistry and biophysics     Volume:  517     ISSN:  1096-0384     ISO Abbreviation:  Arch. Biochem. Biophys.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-09     Completed Date:  2012-03-05     Revised Date:  2014-09-16    
Medline Journal Info:
Nlm Unique ID:  0372430     Medline TA:  Arch Biochem Biophys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  83-97     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Bacteria / metabolism
Biological Evolution*
Biological Transport, Active
Biophysical Phenomena
Carbohydrate Sequence
Cell Membrane / chemistry,  metabolism
Fatty Alcohols / chemistry*,  metabolism*
Macromolecular Substances / chemistry,  metabolism
Models, Biological
Models, Molecular
Molecular Sequence Data
Molecular Structure
Polyisoprenyl Phosphates / chemistry*,  metabolism*
Polysaccharides / metabolism
Grant Support
Reg. No./Substance:
0/Fatty Alcohols; 0/Macromolecular Substances; 0/Polyisoprenyl Phosphates; 0/Polysaccharides

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