| At the membrane frontier: a prospectus on the remarkable evolutionary conservation of polyprenols and polyprenyl-phosphates. | |
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MedLine Citation:
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PMID: 22093697 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Long-chain polyprenols and polyprenyl-phosphates are ubiquitous and essential components of cellular membranes throughout all domains of life. Polyprenyl-phosphates, which include undecaprenyl-phosphate in bacteria and the dolichyl-phosphates in archaea and eukaryotes, serve as specific membrane-bound carriers in glycan biosynthetic pathways responsible for the production of cellular structures such as N-linked protein glycans and bacterial peptidoglycan. Polyprenyl-phosphates are the only form of polyprenols with a biochemically-defined role; however, unmodified or esterified polyprenols often comprise significant percentages of the cellular polyprenol pool. The strong evolutionary conservation of unmodified polyprenols as membrane constituents and polyprenyl-phosphates as preferred glycan carriers in biosynthetic pathways is poorly understood. This review surveys the available research to explore why unmodified polyprenols have been conserved in evolution and why polyprenyl-phosphates are universally and specifically utilized for membrane-bound glycan assembly. |
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Authors:
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Meredith D Hartley; Barbara Imperiali |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2011-11-10 |
Journal Detail:
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Title: Archives of biochemistry and biophysics Volume: 517 ISSN: 1096-0384 ISO Abbreviation: Arch. Biochem. Biophys. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-09 Completed Date: 2012-03-05 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 0372430 Medline TA: Arch Biochem Biophys Country: United States |
Other Details:
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Languages: eng Pagination: 83-97 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Biology and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacteria / metabolism Biological Evolution* Biological Transport, Active Biophysical Phenomena Carbohydrate Sequence Cell Membrane / chemistry, metabolism Fatty Alcohols / chemistry*, metabolism* Humans Macromolecular Substances / chemistry, metabolism Models, Biological Models, Molecular Molecular Sequence Data Molecular Structure Polyisoprenyl Phosphates / chemistry*, metabolism* Polysaccharides / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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GM039334/GM/NIGMS NIH HHS; R01 GM039334-24/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Alcohols; 0/Macromolecular Substances; 0/Polyisoprenyl Phosphates; 0/Polysaccharides |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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