Document Detail

At the heart of the budding yeast cell cycle.
MedLine Citation:
PMID:  8909137     Owner:  NLM     Status:  MEDLINE    
It might now seem obvious that the mechanisms regulating cell division would be found to be a highly conserved feature of eukaryotic cells. This was less clear 20 years ago when the pioneering genetic studies of the cell cycle were initiated. This article presents one view as to what lies at the heart of the budding yeast cell cycle. It is written on the premise that most of the key players, such as cyclin-dependent kinases, the anaphase-promoting complex, the origin recognition complex, Cdc6p and Mcm proteins, were performing similar functions in the common ancestor of yeast and man. Ideas about the budding yeast cell cycle might, therefore, have universal significance for other eukaryotic cells.
K Nasmyth
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Trends in genetics : TIG     Volume:  12     ISSN:  0168-9525     ISO Abbreviation:  Trends Genet.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1996-12-17     Completed Date:  1996-12-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8507085     Medline TA:  Trends Genet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  405-12     Citation Subset:  IM    
I.M.P., Vienna, Austria.
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MeSH Terms
Cell Cycle / genetics*
Cell Division / genetics
Cyclin-Dependent Kinases / genetics,  metabolism
Cyclins / metabolism
DNA Replication
Genes, Fungal*
Genome, Fungal
S Phase
Saccharomyces cerevisiae / cytology,  genetics*
Schizosaccharomyces / cytology,  genetics*
Reg. No./Substance:
0/Cyclins; EC Kinases

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