| Asynergy in coronary heart disease. Evolving clinical and pathophysiologic concepts. | |
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MedLine Citation:
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PMID: 410336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The widespread use of cardiac ventriculography has focused interest on the frequency with which asynergy accompanies coronary heart disease as well as on its clinical and prognostic implications and dynamic nature. Recently, "intervention ventriculography" using nitroglycerin or postextrasystolic potentiation has indicated that asynergic zones may be more accurately classified as reversible (implying viable myocardium) or irreversible (nonviable or scarred myocardium), and thus the ventriculographic definition of aneurysm must reflect not only the severity of asynergy but its contractile reserve. Surface electrocardiogram Q waves, the severity of asynergy, and degree of coronary occlusion all adversely affect the potential for reversibility, whereas coronary collaterals enhance it. Important clinical applications include assessment of the potential utility of coronary bypass surgery in improving asynergy and of vasodilators in the treatment of patients with left ventricular failure. With refractory sequelae of aneurysms (heart failure, ventricular tachyarrhythmias, and systemic emboli) and a discrete aneurysm, surgical resection has been increasingly used with generally good results. |
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Authors:
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R H Helfant; M M Bodenheimer; V S Banka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of internal medicine Volume: 87 ISSN: 0003-4819 ISO Abbreviation: Ann. Intern. Med. Publication Date: 1977 Oct |
Date Detail:
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Created Date: 1977-11-25 Completed Date: 1977-11-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372351 Medline TA: Ann Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 475-82 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arrhythmias, Cardiac
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physiopathology Collateral Circulation Coronary Artery Bypass Coronary Circulation Coronary Disease / physiopathology*, surgery Coronary Vessels / physiopathology Electrocardiography Heart Aneurysm / etiology, surgery Heart Conduction System / drug effects, physiopathology* Heart Failure / etiology, therapy Heart Ventricles / physiopathology Humans Ischemia Myocardial Contraction / drug effects Nitroglycerin / pharmacology, therapeutic use Prognosis |
| Chemical | |
Reg. No./Substance:
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55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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