Document Detail

Asynchronous pentobarbital-induced burst suppression with corpus callosum hemorrhage.
MedLine Citation:
PMID:  10402090     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We describe the electroencephalographic (EEG) findings in a 9-year-old girl, who presented with generalized tonic-clonic status epilepticus requiring pentobarbital anesthesia, and correlate these findings with clinicoradiologic evidence of a ruptured AVM with hemorrhage into the body of the corpus callosum. METHODS: EEG analysis accompanied by clinical assessment, CT and MRI scans, and cerebral angiography were performed. RESULTS: With pentobarbital coma, the EEG showed burst suppression with prominent interhemispheric asynchrony. Suppression epochs >2 s in duration and with amplitude <20 microV in all channels were identified. In 12 min of the EEG analyzed, 6 unilateral and 20 bilateral epochs occurred. Of the 20 bilateral suppression epochs, interhemispheric asynchrony of >1 s was noted at onset for 5 epochs and at offset for one. Chi-square analysis revealed an equal tendency for unilateral suppressions to occur over either hemisphere, and for suppression in one hemisphere to begin before the other. CONCLUSIONS: We conclude that the corpus callosum plays a critical role in interhemispheric synchronization of cortical neuronal electrical activity and propose that: (1) normally, the corpus callosum modulates interhemispheric synchronization of cortical inhibition; and (2) with corpus callosal disruption, cortical areas are 'released' from such synchronization.
L M Lazar; L M Milrod; G E Solomon; D R Labar
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  110     ISSN:  1388-2457     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-08-02     Completed Date:  1999-08-02     Revised Date:  2008-09-10    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  1036-40     Citation Subset:  IM    
Comprehensive Epilepsy Center, The New York Hospital-Cornell University Medical Center, NY 10021, USA.
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MeSH Terms
Cerebral Hemorrhage / radiography*
Corpus Callosum / radiography*
Electroencephalography / drug effects*
Epilepsy / drug therapy,  physiopathology*,  radiography*
Pentobarbital / therapeutic use*
Tomography, X-Ray Computed
Reg. No./Substance:
Comment In:
Clin Neurophysiol. 2000 Feb;111(2):367   [PMID:  10680574 ]

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